Journal article
Bravo catheter-free pH monitoring: normal values, concordance, optimal diagnostic thresholds, and accuracy
Clinical gastroenterology and hepatology, v 7(1), pp 60-67
Jan 2009
PMID: 18976965
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The Bravo pH capsule is a catheter-free intraesophageal pH monitoring system that avoids the discomfort of an indwelling catheter. The objectives of this study were as follows: (1) to obtain normal values for the first and second 24-hour recording periods using a Bravo capsule placed transnasally 5 cm above the upper border of the lower esophageal sphincter determined by manometry and to assess concordance between the 2 periods, (2) to determine the optimal discriminating threshold for identifying patients with gastroesophageal reflux disease (GERD), and (3) to validate this threshold and to identify the recording period with the greatest accuracy.
Normal values for a manometrically positioned, transnasally inserted Bravo capsule were determined in 50 asymptomatic subjects. A test population of 50 subjects (25 asymptomatic, 25 with GERD) then was monitored to determine the best discriminating thresholds. The thresholds for the first, second, and combined (48-hour) recording periods then were validated in a separate group of 115 patients.
In asymptomatic subjects, the values measured using a manometrically positioned Bravo pH capsule were similar between the first and second 24-hour periods of recording. The highest level of accuracy with Bravo was observed when an abnormal composite pH score was obtained in the first or second 24-hour period of monitoring.
Normal values for esophageal acid exposure were defined for a manometrically positioned, transnasally inserted, Bravo pH capsule. An abnormal composite pH score, obtained in either the first or second 24-hour recording period, was the most accurate method of identifying patients with GERD.
Metrics
Details
- Title
- Bravo catheter-free pH monitoring: normal values, concordance, optimal diagnostic thresholds, and accuracy
- Creators
- Shahin Ayazi - University of Southern CaliforniaJohn C Lipham - University of Southern CaliforniaGiuseppe Portale - University of Southern CaliforniaChristian G Peyre - University of Southern CaliforniaChristopher G Streets - University of Southern CaliforniaJessica M Leers - University of Southern CaliforniaSteven R Demeester - University of Southern CaliforniaFarzaneh Banki - University of Southern CaliforniaLinda S Chan - University of Southern CaliforniaJeffrey A Hagen - University of Southern CaliforniaTom R Demeester - University of Southern California
- Publication Details
- Clinical gastroenterology and hepatology, v 7(1), pp 60-67
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:000262822000012
- Scopus ID
- 2-s2.0-58049191399
- Other Identifier
- 991022048377604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Gastroenterology & Hepatology