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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Breast Cancer Brain Metastasis Response to Radiation After Microbubble Oxygen Delivery in a Murine Model
Journal of ultrasound in medicine, v 38(12), pp 3221-3228
Dec 2019
PMID: 31124171
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives
Hypoxic cancer cells have been shown to be more resistant to radiation therapy than normoxic cells. Hence, this study investigated whether ultrasound (US)‐induced rupture of oxygen‐carrying microbubbles (MBs) would enhance the response of breast cancer metastases to radiation.
Methods
Nude mice (n = 15) received stereotactic injections of brain‐seeking MDA‐MB‐231 breast cancer cells into the right hemisphere. Animals were randomly assigned into 1 of 5 treatment groups: no intervention, 10 Gy radiation using a small‐animal radiation research platform, nitrogen‐carrying MBs combined with US‐mediated MB rupture immediately before 10 Gy radiation, oxygen‐carrying MBs immediately before 10 Gy radiation, and oxygen‐carrying MBs with US‐mediated MB rupture immediately before 10 Gy radiation. Tumor progression was monitored with 3‐dimensional US, and overall survival was noted.
Results
All groups except those treated with oxygen‐carrying MB rupture and radiation had continued rapid tumor growth after treatment. Tumors treated with radiation alone showed a mean increase in volume ± SD of 337% ± 214% during the week after treatment. Tumors treated with oxygen‐carrying MBs and radiation without MB rupture showed an increase in volume of 383% ± 226%. Tumors treated with radiation immediately after rupture of oxygen‐carrying MBs showed an increase in volume of only 41% ± 1% (P = 0.045), and this group also showed a 1 week increase in survival time.
Conclusions
Adding US‐ruptured oxygen‐carrying MBs to radiation therapy appears to delay tumor progression and improve survival in a murine model of metastatic breast cancer.
Metrics
Details
- Title
- Breast Cancer Brain Metastasis Response to Radiation After Microbubble Oxygen Delivery in a Murine Model
- Creators
- Lauren J. Delaney - Thomas Jefferson UniversityLorela Ciraku - Drexel UniversityBrian E. Oeffinger - Drexel UniversityCorinne E. Wessner - Thomas Jefferson UniversityJi‐Bin Liu - Thomas Jefferson UniversityJingzhi Li - Thomas Jefferson UniversityKibo Nam - Thomas Jefferson UniversityFlemming Forsberg - Thomas Jefferson UniversityDennis B. Leeper - Thomas Jefferson UniversityPatrick O'Kane - Thomas Jefferson UniversityMargaret A. Wheatley - Drexel UniversityMauricio J. Reginato - Drexel UniversityJohn R. Eisenbrey - Thomas Jefferson University
- Publication Details
- Journal of ultrasound in medicine, v 38(12), pp 3221-3228
- Publisher
- John Wiley & Sons, Inc
- Number of pages
- 8
- Grant note
- National Institutes of Health (R01 EB026881; F32 AR072491) Sidney Kimmel Cancer Center at Thomas Jefferson University
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000496764800014
- Scopus ID
- 2-s2.0-85075108068
- Other Identifier
- 991019169672904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Acoustics
- Radiology, Nuclear Medicine & Medical Imaging