Journal article
Brief Report: Willingness to Accept HIV-Infected and Increased Infectious Risk Donor Organs Among Transplant Candidates Living With HIV
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, v 85(1)
01 Sep 2020
PMID: 32427721
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: HIV-infected (HIV+) donor to HIV+ recipient (HIV D+/R+) transplantation might improve access to transplantation for people living with HIV. However, it remains unknown whether transplant candidates living with HIV will accept the currently unknown risks of HIV D+/R+ transplantation. Methods: We surveyed transplant candidates living with HIV from 9 US transplant centers regarding willingness to accept HIV+ donor organs. Results: Among 116 participants, the median age was 55 years, 68% were men, and 78% were African American. Most were willing to accept HIV+ living donor organs (87%), HIV+ deceased donor organs (84%), and increased infectious risk donor organs (70%). Some (30%) were concerned about HIV superinfection; even among these respondents, 71% were willing to accept an HIV D+ organ. Respondents from centers that had already performed a transplant under an HIV D+/R+ transplantation research protocol were more willing to accept HIV+ deceased donor organs (89% vs. 71%,P= 0.04). Respondents who chose not to enroll in an HIV D+/R+ transplantation research protocol were less likely to believe that HIV D+/R+ transplantation was safe (45% vs. 77%,P= 0.02), and that HIV D+ organs would work similar to HIV D- organs (55% vs. 77%,P= 0.04), but more likely to believe they would receive an infection other than HIV from an HIV D+ organ (64% vs. 13%,P< 0.01). Conclusions: Willingness to accept HIV D+ organs among transplant candidates living with HIV does not seem to be a major barrier to HIV D+/R+ transplantation and may increase with growing HIV D+/R+ transplantation experience.
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Details
- Title
- Brief Report: Willingness to Accept HIV-Infected and Increased Infectious Risk Donor Organs Among Transplant Candidates Living With HIV
- Publication Details
- JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, v 85(1)
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS; PHILADELPHIA
- Number of pages
- 0
- Grant note
- This work was supported by The Greenwall Foundation Making a Difference grant (J.S.), grant numbers 1P30AI094189 (Johns Hopkins Center for AIDS Research), 1R01AI120938 (A.A.R.T.), U01AI138897 (C.M.D./D.L.S.), and U01AI134591 (C.M.D./D.L.S.) from the National Institute of Allergy and Infectious Diseases, grant number K23CA177321 (C.M.D.) from the National Cancer Institute, and grant numbers K24DK101828 (D.L.S.) and K01DK101677 (A.B.M.) from the National Institute of Diabetes and Digestive and Kidney Diseases. The analyses described here are the responsibility of the authors alone and do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000571130000018
- Scopus ID
- 2-s2.0-85088382569
- Other Identifier
- 991021860674404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases