Journal article
Broad-Spectrum Anti-Human Immunodeficiency Virus (HIV) Potential of a Peptide HIV Type 1 Entry Inhibitor
Journal of virology, v 81(7), pp 3645-3648
Apr 2007
PMID: 17251295
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The AIDS epidemic continues to spread at an alarming rate worldwide, especially in developing countries. One approach to solving this problem is the generation of anti-human immunodeficiency virus (HIV) compounds with inhibition spectra broad enough to include globally prevailing forms of the virus. We have examined the HIV type 1 (HIV-1) envelope specificity of a recently identified entry inhibitor candidate, HNG-105, using surface plasmon resonance spectroscopy and pseudovirus inhibition assays. The combined results suggest that the HNG-105 molecule may be effective across the HIV-1 subtypes, and they highlight its potential as a lead for developing therapeutic and microbicidal agents to help combat the spread of AIDS.
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Details
- Title
- Broad-Spectrum Anti-Human Immunodeficiency Virus (HIV) Potential of a Peptide HIV Type 1 Entry Inhibitor
- Creators
- Simon Cocklin - Department of Biochemistry and Molecular BiologyHosahudya Gopi - Department of Biochemistry and Molecular BiologyBianca Querido - Department of Biochemistry and Molecular BiologyManideepthi Nimmagadda - Department of Biochemistry and Molecular BiologySyna Kuriakose - Department of Biochemistry and Molecular BiologyClaudia Cicala - Department of Biochemistry and Molecular BiologySandya Ajith - Department of Biochemistry and Molecular BiologySabine Baxter - Department of Biochemistry and Molecular BiologyJames Arthos - Department of Biochemistry and Molecular BiologyJulio Martín-García - Department of Biochemistry and Molecular BiologyIrwin M Chaiken - Department of Biochemistry and Molecular Biology
- Publication Details
- Journal of virology, v 81(7), pp 3645-3648
- Publisher
- American Society for Microbiology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; Microbiology and Immunology
- Web of Science ID
- WOS:000244988100061
- Scopus ID
- 2-s2.0-33947433186
- Other Identifier
- 991014877930204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Virology