Journal article
Bubble nucleation in lipid bilayers: A mechanism for low frequency ultrasound disruption
Biochimica et biophysica acta. Biomembranes, v 1828(4), pp 1192-1197
Apr 2013
PMID: 23313452
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recent experiments have shown that low frequency ultrasound (LFUS) induces leakage from lipid vesicles. However, the mechanism by which LFUS disrupts the lipid bilayer structure is not clear. In this paper we develop a theoretical model to test the possibility that gas molecule partitioning from the aqueous media into the lipid bilayer core can lead to the nucleation of microscale gas bubbles. If those can, indeed, form, then their presence in the lipid bilayer and interactions with an ultrasound field can cause bilayer disruption and leakage. The model derived here for the nucleation of stable bubbles accounts for the ‘surface tension’ that the lipid bilayer exerts on the bubble, a result of the associated disruption of the lipid packing. The model predicts that the probability of bubble nucleation is highly sensitive to the bilayer thickness, and largely insensitive to the bilayer phase. The probability of stable bubble formation is shown to correlate with experimentally measured sensitivity of lipid bilayers to LFUS, suggesting that membrane disruption may be due to embedded bubbles that nucleated in the bilayer.
[Display omitted]
► Gas molecules partition into lipid bilayers, where they can form micro bubbles. ► Bubble formation is controlled by a surface tension arising from lipid deformation. ► Bubble formation probability is found to be highly sensitive to bilayer thickness. ► Bubble formation probability correlates with measured US-induced leakage.
Metrics
Details
- Title
- Bubble nucleation in lipid bilayers: A mechanism for low frequency ultrasound disruption
- Creators
- Steven P WrennEleanor SmallNily Dan
- Publication Details
- Biochimica et biophysica acta. Biomembranes, v 1828(4), pp 1192-1197
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:000316522100002
- Scopus ID
- 2-s2.0-84873045853
- Other Identifier
- 991014878193904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics