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Accepted (AM)Open Access (License Unspecified), Open
Journal article
C-reactive protein and coronary artery calcium in asymptomatic women with systemic lupus erythematosus or rheumatoid arthritis
The American journal of cardiology, v 102(6), pp 755-760
15 Sep 2008
PMID: 18774002
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Patients with systemic lupus erythematosus (SLE) and those with rheumatoid arthritis (RA) have increased risk for atherosclerotic cardiovascular disease. The aims of this study were to compare the presence of coronary artery calcium (CAC) in age- and race-matched women with SLE, those with RA, and healthy controls without diabetes mellitus or history of myocardial infarction, angina pectoris, or stroke and to investigate its relation with traditional risk factors, inflammation, and endothelial activation. Study subjects completed cardiovascular risk factor assessment and electron-beam computed tomography that measured CAC. The 2 patient groups had similar prevalence and extent of CAC as well as significantly increased odds of having any CAC (odds ratio 1.87, 95% confidence interval 1.09 to 3.21) and more extensive CAC (odds ratio 4.04, 95% confidence interval 1.42 to 11.56 for CAC score > 100) compared with healthy controls. After controlling for differences in cardiovascular risk factors, including insulin resistance and hypertension, the results remained statistically significant. After adjustment for differences in levels of C-reactive protein and/or soluble intercellular adhesion molecule-1, however, women with chronic inflammatory diseases no longer had significantly increased odds of having any CAC or more extensive CAC compared with controls. In conclusion, asymptomatic and nondiabetic women with chronic inflammatory diseases had significantly increased odds of having CAC and more extensive CAC compared with age- and race-matched healthy controls. The increased odds for CAC may in part result from higher levels of inflammation and endothelial activation in these patients. (C) 2008 Elsevier Inc. All rights reserved.
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Details
- Title
- C-reactive protein and coronary artery calcium in asymptomatic women with systemic lupus erythematosus or rheumatoid arthritis
- Creators
- Amy H. Kao - University of PittsburghMary Chester M. Wasko - University of PittsburghShanthi Krishnaswami - Medical College of WisconsinJoseph Wagner - Wright State UniversityDaniel Edmundowicz - University of PittsburghPenny Shaw - University of PittsburghAmy Lynn Cunningham - La Salle UniversityNatalya Danchenko - University of PittsburghKim Sutton-Tyrrell - University of PittsburghRussell P. Tracy - University of VermontLewis H. Kuller - University of PittsburghSusan Manzi - University of Pittsburgh
- Publication Details
- The American journal of cardiology, v 102(6), pp 755-760
- Publisher
- Elsevier
- Number of pages
- 6
- Grant note
- American College of Rheumatology's Research and Education Foundation, Atlanta, Georgia 1-P60-AR-4481101 / National Institutes of Health, Bethesda, Maryland; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01 AR46588-01; K24 AR02213-01; K23 AR51044 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA MO1-RR000056 / National Institutes of Health/National Center for Research Resources/General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) 0040149N / American Heart Association, Dallas Texas; American Heart Association Western Pennsylvania Chapter of the Arthritis Foundation, Pittsburgh, Pennsylvania
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Rheumatology; General Internal Medicine
- Web of Science ID
- WOS:000259689900022
- Scopus ID
- 2-s2.0-50949094184
- Other Identifier
- 991021933905004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems