Journal article
CCAAT/enhancer-binding proteins and the pathogenesis of retrovirus infection
Future microbiology, v 4(3), pp 299-321
Apr 2009
PMID: 19327116
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Previous studies indicate that two upstream CCAAT/enhancer-binding protein (C/EBP) sites and C/EBPβ are required for subtype B HIV-1 gene expression in cells of the monocyte–macrophage lineage. The mechanisms of C/EBP regulation of HIV-1 transcription and replication remain unclear. This review focuses on studies concerning the role of C/EBP factors in HIV-1, human T-cell leukemia virus type 1, and SIV transcription in various cell types and tissues cultured
in vitro
, animal models and during human infection. The structure and function of the C/EBPβ gene and the related protein isoforms are discussed along with the transcription factors, coactivators, viral proteins, cytokines and chemokines that affect C/EBP function.
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Details
- Title
- CCAAT/enhancer-binding proteins and the pathogenesis of retrovirus infection
- Creators
- Yujie Liu - Department of Microbiology & Immunology, Center for Molecular Virology & Neuroimmunology, Center for Cancer Biology, Philadelphia, PA 19129, USAMichael R Nonnemacher - Department of Microbiology & Immunology, Center for Molecular Virology & Neuroimmunology, Center for Cancer Biology, Philadelphia, PA 19129, USABrian Wigdahl - Department of Microbiology & Immunology, Center for Molecular Virology & Neuroimmunology, Center for Cancer Biology, Philadelphia, PA 19129, USA, Tel.: +1 215 762 8399, Fax: +1 215 762 1955
- Publication Details
- Future microbiology, v 4(3), pp 299-321
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000265342700009
- Scopus ID
- 2-s2.0-65549140316
- Other Identifier
- 991014877650004721
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- Web of Science research areas
- Microbiology