Journal article
CCAAT/enhancer-binding proteins modulate human T cell leukemia virus type 1 long terminal repeat activation
Virology (New York, N.Y.), v 348(2), pp 354-369
2006
PMID: 16458341
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
CCAAT/enhancer-binding protein (C/EBP) basic region/leucine zipper (bZIP) transcription factors have been shown to form heterodimers with cAMP-responsive element binding protein 2 (CREB-2), a transcription factor involved in regulating basal and Tax-mediated transactivation of the human T cell leukemia virus type 1 (HTLV-1) long terminal repeat (LTR). In cells of the monocyte–macrophage lineage (proposed to play a role in HTLV-1 pathogenesis as an accessory target cell), several members of the C/EBP family are expressed at high levels and may have functional impact on both basal and Tax-mediated transactivation of the HTLV-1 LTR. Basal activation of the HTLV-1 LTR was enhanced by overexpression of C/EBPβ, C/EBPδ, or C/EBPε, whereas transactivation of the LTR by Tax was inhibited by overexpression of C/EBPα and C/EBPβ. Inhibition of Tax-mediated transactivation of the HTLV-1 LTR was co-activator-independent, did not require C/EBP binding to the Tax-responsive elements, and may involve heterodimerization with CREB factors.
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Details
- Title
- CCAAT/enhancer-binding proteins modulate human T cell leukemia virus type 1 long terminal repeat activation
- Creators
- Christian Grant - Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USAMichael Nonnemacher - Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USAPooja Jain - Department of Microbiology and Immunology, Center for Molecular Virology and Neuroimmunology, Center for Cancer Biology, Drexel University College of Medicine, Philadelphia, PA 19129, USADevanshi Pandya - Department of Microbiology and Immunology, Center for Molecular Virology and Neuroimmunology, Center for Cancer Biology, Drexel University College of Medicine, Philadelphia, PA 19129, USABryan Irish - Department of Microbiology and Immunology, Center for Molecular Virology and Neuroimmunology, Center for Cancer Biology, Drexel University College of Medicine, Philadelphia, PA 19129, USASimon C Williams - Department of Cell Biology and Biochemistry, Texas Tech. University Health Sciences Center, Lubbock, TX 79430, USABrian Wigdahl - Department of Microbiology and Immunology, Center for Molecular Virology and Neuroimmunology, Center for Cancer Biology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
- Publication Details
- Virology (New York, N.Y.), v 348(2), pp 354-369
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000237819200009
- Scopus ID
- 2-s2.0-33646243209
- Other Identifier
- 991014877666504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Virology