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Accepted (AM)Open Access (License Unspecified), Open
Journal article
CCR5 Receptor Antagonists Block Metastasis to Bone of v-Src Oncogene-Transformed Metastatic Prostate Cancer Cell Lines
Cancer research (Chicago, Ill.), v 74(23), pp 7103-7114
01 Dec 2014
PMID: 25452256
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Src family kinases (SFK) integrate signal transduction for multiple receptors, regulating cellular proliferation, invasion, and metastasis in human cancer. Although Src is rarely mutated in human prostate cancer, SFK activity is increased in the majority of human prostate cancers. To determine the molecular mechanisms governing prostate cancer bone metastasis, FVB murine prostate epithelium was transduced with oncogenic v-Src. The prostate cancer cell lines metastasized in FVB mice to brain and bone. Gene expression profiling of the tumors identified activation of a CCR5 signaling module when the prostate epithelial cell lines were grown in vivo versus tissue cultures. The whole body, bone, and brain metastatic prostate cancer burden was reduced by oral CCR5 antagonist. Clinical trials of CCR5 inhibitors may warrant consideration in patients with CCR5 activation in their tumors. (C)2014 AACR.
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Details
- Title
- CCR5 Receptor Antagonists Block Metastasis to Bone of v-Src Oncogene-Transformed Metastatic Prostate Cancer Cell Lines
- Creators
- Daniela Sicoli - Thomas Jefferson UniversityXuanmao Jiao - Thomas Jefferson UniversityXiaoming Ju - Thomas Jefferson UniversityMarco Velasco-Velazquez - National Autonomous University of MexicoAdam Ertel - Thomas Jefferson UniversitySankar Addya - Thomas Jefferson UniversityZhiping Li - Thomas Jefferson UniversitySebastiano Ando - University of CalabriaAlessandro Fatatis - Thomas Jefferson UniversityBishnuhari Paudyal - Thomas Jefferson UniversityMassimo Cristofanilli - Thomas Jefferson UniversityMathew L. Thakur - Thomas Jefferson UniversityMichael P. Lisanti - Thomas Jefferson UniversityRichard G. Pestell - Thomas Jefferson University
- Publication Details
- Cancer research (Chicago, Ill.), v 74(23), pp 7103-7114
- Publisher
- Amer Assoc Cancer Research
- Number of pages
- 12
- Grant note
- IN219613 / PAPIIT-UNAM; Programa de Apoyo a Proyectos de Investigacion e Innovacion Tecnologica (PAPIIT); Universidad Nacional Autonoma de Mexico R01CA132115 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R01CA070896; R01CA075503; R01CA132115; R01CA107382; R01CA086072; R01CA120876 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P30CA056036 / Kimmel Cancer Center NIH Cancer Center Core grant Dr. Ralph and Marian C. Falk Medical Research Trust Pennsylvania Department of Health Margaret Q. Landenberger Research Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000346362400034
- Scopus ID
- 2-s2.0-84918564403
- Other Identifier
- 991019168191104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology