Files and links (1)
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_CCR5_Antagonist_Blocks_Metastasis_of_Basal_Breast_Cancer_Cells/22393284
SubmittedCC BY V4.0, Open
Journal article
CCR5 antagonist blocks metastasis of basal breast cancer cells
Cancer research (Chicago, Ill.), v 72(15), pp 3839-3850
01 Aug 2012
PMID: 22637726
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The roles of the chemokine CCL5 and its receptor CCR5 in breast cancer progression remain unclear. Here, we conducted microarray analysis on 2,254 human breast cancer specimens and found increased expression of CCL5 and its receptor CCR5, but not CCR3, in the basal and HER-2 genetic subtypes. The subpopulation of human breast cancer cell lines found to express CCR5 displayed a functional response to CCL5. In addition, oncogene transformation induced CCR5 expression, and the subpopulation of cells that expressed functional CCR5 also displayed increased invasiveness. The CCR5 antagonists maraviroc or vicriviroc, developed to block CCR5 HIV coreceptor function, reduced in vitro invasion of basal breast cancer cells without affecting cell proliferation or viability, and maraviroc decreased pulmonary metastasis in a preclinical mouse model of breast cancer. Taken together, our findings provide evidence for the key role of CCL5/CCR5 in the invasiveness of basal breast cancer cells and suggest that CCR5 antagonists may be used as an adjuvant therapy to reduce the risk of metastasis in patients with the basal breast cancer subtype.
Metrics
Details
- Title
- CCR5 antagonist blocks metastasis of basal breast cancer cells
- Creators
- Marco Velasco-Velázquez - Thomas Jefferson UniversityXuanmao JiaoMarisol De La FuenteTimothy G PestellAdam ErtelMichael P LisantiRichard G Pestell
- Publication Details
- Cancer research (Chicago, Ill.), v 72(15), pp 3839-3850
- Publisher
- American Association for Cancer Research (AACR)
- Grant note
- R01CA070896 / NCI NIH HHS R01CA132115 / NCI NIH HHS P30CA056036 / NCI NIH HHS R01CA086072 / NCI NIH HHS R01CA107382 / NCI NIH HHS R01CA120876 / NCI NIH HHS R01CA075503 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000307354100015
- Scopus ID
- 2-s2.0-84864863792
- Other Identifier
- 991019176643904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology