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CD28 and CD27 costimulation of CD8+ T cells: a story of survival
Journal article   Peer reviewed

CD28 and CD27 costimulation of CD8+ T cells: a story of survival

Douglas V Dolfi and Peter D Katsikis
Advances in experimental medicine and biology, v 590
2007
DOI: https://doi.org/10.1007/978-0-387-34814-8_11
PMID: 17191384
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Animals B7-1 Antigen - genetics B7-1 Antigen - immunology CD27 Ligand - genetics CD27 Ligand - immunology CD28 Antigens - immunology CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology Cell Differentiation Cell Lineage Cell Survival Epitopes, T-Lymphocyte - immunology Humans Immunologic Memory Lymphocyte Activation Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - physiology Mice Mice, Transgenic Models, Immunological Receptor-CD3 Complex, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - immunology Signal Transduction - immunology T-Cell Antigen Receptor Specificity Thymus Gland - cytology Thymus Gland - immunology Tumor Necrosis Factor Receptor Superfamily, Member 7 - genetics Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology Virus Diseases - immunology
Although the requirement of CD28 and CD27 costimulation has been clearly demonstrated during primary CD8+ T cell responses and this costimulation acts by providing proliferation and survival cues to naive CD8+ T cells, a number of questions also arise from these studies. Is the requirement for CD28 and CD27 costimulation restricted to the initiation of the immune response in the lymph nodes, where presumably the initial contact between naive CD8+ T cell and DC occurs? What is the purpose of the dramatic influx of DC to sites of inflammation such as the lung during influenza virus infection and the formation of inflammatory BALT (iBALT)?(104) Are such DC at the site of inflammation and at later stages of the immune response providing cytokines or costimulation to effector CD8+ T cells? If DC are required for optimal secondary responses (100), is CD28 costimulation the missing signal or is it other members of the B7:CD28 family or TNF family? Given that a number of investigators are actively addressing these questions, the answers we expect will be soon to come and open exciting new opportunities for immune enhancement or dampening strategies and vaccine adjuvants.

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21 citations in Web of Science
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Web of Science research areas
Immunology
Medicine, Research & Experimental
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