Journal article
CD4+ T Cells Are Required for the Priming of CD8+ T Cells following Infection with Herpes Simplex Virus Type 1
Journal of virology, v 83(10), pp 5256-5268
May 2009
PMID: 19279095
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The role of CD4
+
helper T cells in modulating the acquired immune response to herpes simplex virus type 1 (HSV-1) remains ill defined; in particular, it is unclear whether CD4
+
T cells are needed for the generation of the protective HSV-1-specific CD8
+
-T-cell response. This study examined the contribution of CD4
+
T cells in the generation of the primary CD8
+
-T-cell responses following acute infection with HSV-1. The results demonstrate that the CD8
+
-T-cell response generated in the draining lymph nodes of CD4
+
-T-cell-depleted C57BL/6 mice and B6-MHC-II
−/−
mice is quantitatively and qualitatively distinct from the CD8
+
T cells generated in normal C57BL/6 mice. Phenotypic analyses show that virus-specific CD8
+
T cells express comparable levels of the activation marker CD44 in mice lacking CD4
+
T cells and normal mice. In contrast, CD8
+
T cells generated in the absence of CD4
+
T cells express the interleukin 2 receptor α-chain (CD25) at lower levels. Importantly, the CD8
+
T cells in the CD4
+
-T-cell-deficient environment are functionally active with respect to the expression of cytolytic activity in vivo but exhibit a diminished capacity to produce gamma interferon and tumor necrosis factor alpha. Furthermore, the primary expansion of HSV-1-specific CD8
+
T cells is diminished in the absence of CD4
+
-T-cell help. These results suggest that CD4
+
-T-cell help is essential for the generation of fully functional CD8
+
T cells during the primary response to HSV-1 infection.
Metrics
Details
- Title
- CD4+ T Cells Are Required for the Priming of CD8+ T Cells following Infection with Herpes Simplex Virus Type 1
- Creators
- Naveen K Rajasagi - Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130Sadik H Kassim - Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130Christina M Kollias - Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130Xiangyi Zhao - Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130Robert Chervenak - Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130Stephen R Jennings - Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130
- Publication Details
- Journal of virology, v 83(10), pp 5256-5268
- Publisher
- American Society for Microbiology (ASM)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000265407700050
- Scopus ID
- 2-s2.0-65349181344
- Other Identifier
- 991014877664804721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Virology