Journal article
CD4+ T cell responses to interleukin-2 administration in HIV-infected patients are directly related to the baseline level of immune activation
The Journal of infectious diseases, v 196(5), pp 677-683
01 Sep 2007
PMID: 17674308
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Intermittent interleukin (IL)-2 administration to human immunodeficiency virus (HIV)-infected patients leads to CD4(+) T cell expansions. The factors potentially affecting these expansions were investigated in the present study.
A matched (for baseline CD4(+) T cell count) case-control study was designed. Nonresponders (NRs) were defined as patients with a <or=10% increase in CD4(+) T cell count 2 months after the third IL-2 cycle (week 24), compared with that at baseline (week 0). Control subjects experienced a >or=50% increase in CD4(+) T cell count at week 24. Immunophenotype, Ki67 and forkhead box protein P3 (FoxP3) expression, and T cell receptor excision circle (TREC) measurements in T cells were evaluated at weeks 0 and 24 in both groups.
Control subjects and NRs did not differ significantly at baseline in age, viral load, CD4(+) T cell count, nadir CD4(+) T cell count, or CD8(+) T cell count. At week 0, NRs had lower TREC levels per 1x106 T cells and higher levels of T cell proliferation and activation than did control subjects. At week 24, both groups experienced decreases in T cell proliferation and increases in CD25 and FoxP3 expression on CD4(+) T cells, with TREC levels per 1x106 CD4(+) T cells decreasing significantly only in control subjects.
Increased immune activation can adversely affect CD4(+) T cell expansions after IL-2 administration. Despite the lack of expansion, other evidence of IL-2-induced biological activity was observed.
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Details
- Title
- CD4+ T cell responses to interleukin-2 administration in HIV-infected patients are directly related to the baseline level of immune activation
- Creators
- Irini Sereti - National Institute of Allergy and Infectious DiseasesPeter Sklar - Drexel UniversityMeena S Ramchandani - Drexel UniversitySarah W Read - National Institutes of HealthVinay Aggarwal - National Institutes of HealthHiromi Imamichi - National Institutes of HealthVen Natarajan - National Institutes of HealthJulia A Metcalf - National Institutes of HealthJoseph A Kovacs - Science Applications International CorporationJorge Tavel - National Institutes of HealthRichard T Davey - National Institutes of HealthRebecca Dersimonian - National Institutes of HealthH Clifford Lane - Science Applications International Corporation
- Publication Details
- The Journal of infectious diseases, v 196(5), pp 677-683
- Grant note
- Intramural NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:000248557600005
- Scopus ID
- 2-s2.0-34548058080
- Other Identifier
- 991019173987704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology