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Journal article
CD4(+) T cells reduce the tissue burden of Chlamydia muridarum in male BALB/c mice
Vaccine, v 28(31), pp 4861-4863
12 Jul 2010
PMID: 20653101
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Male chlamydial infections are becoming more recognised as an aetiological agent in infertility. An IFN-gamma response is required for protection against Chlamydia in females, but may have the potential to induce pathology in the immune-privileged male reproductive tract. We examined the induction of immunity following intranasal immunisation with major outer membrane protein (MOMP) of Chlamydia muridarum in male BALB/c mice, and the role of MOMP-specific CD4(+) T cells in clearance of an intrapenile infection. Here we report that adoptive transfer of MOMP-specific CD4(+) T cells into naive mice confers partial protective immunity, which significantly reduces the tissue burden of Chlamydia. (C) 2010 Elsevier Ltd. All rights reserved.
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Details
- Title
- CD4(+) T cells reduce the tissue burden of Chlamydia muridarum in male BALB/c mice
- Creators
- Kelly A. Cunningham - Queensland University of TechnologyAlison J. Carey - Queensland University of TechnologyPeter Timms - Queensland University of TechnologyKenneth W. Beagley - Queensland University of Technology
- Publication Details
- Vaccine, v 28(31), pp 4861-4863
- Publisher
- Elsevier
- Number of pages
- 3
- Grant note
- National Health and Medical Research Council; National Health and Medical Research Council (NHMRC) of Australia
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; College of Medicine; Drexel University
- Web of Science ID
- WOS:000280659600002
- Scopus ID
- 2-s2.0-77954756878
- Other Identifier
- 991020100206704721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Medicine, Research & Experimental