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CD4 T follicular helper cell dynamics during SIV infection
Journal article   Open access   Peer reviewed

CD4 T follicular helper cell dynamics during SIV infection

Constantinos Petrovas, Takuya Yamamoto, Michael Y Gerner, Kristin L Boswell, Kaska Wloka, Emily C Smith, David R Ambrozak, Netanya G Sandler, Katherina J Timmer, Xiaoyong Sun, …
The Journal of clinical investigation, v 122(9), pp 3281-3294
Sep 2012
DOI: https://doi.org/10.1172/JCI63039
PMID: 22922258
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
http://www.jci.org/articles/view/63039/files/pdfView
Published, Version of Record (VoR) Open

Abstract

Animals Antibodies, Viral - blood B-Lymphocytes - immunology B-Lymphocytes - metabolism CD4 Antigens - metabolism Cell Death Cell Proliferation Cytokines - metabolism Gene Expression Germinal Center - pathology Germinal Center - virology Host-Pathogen Interactions Lymph Nodes - metabolism Lymph Nodes - pathology Lymph Nodes - virology Macaca mulatta Oligonucleotide Array Sequence Analysis Proto-Oncogene Proteins c-maf - genetics Proto-Oncogene Proteins c-maf - metabolism Receptors, Lysosphingolipid - genetics Receptors, Lysosphingolipid - metabolism Simian Acquired Immunodeficiency Syndrome - blood Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - pathology Simian Immunodeficiency Virus - immunology Simian Immunodeficiency Virus - physiology T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transcriptome
CD4 T follicular helper (TFH) cells interact with and stimulate the generation of antigen-specific B cells. TFH cell interaction with B cells correlates with production of SIV-specific immunoglobulins. However, the fate of TFH cells and their participation in SIV-induced antibody production is not well understood. We investigated the phenotype, function, location, and molecular signature of TFH cells in rhesus macaques. Similar to their human counterparts, TFH cells in rhesus macaques represented a heterogeneous population with respect to cytokine function. In a highly differentiated subpopulation of TFH cells, characterized by CD150lo expression, production of Th1 cytokines was compromised while IL-4 production was augmented, and cells exhibited decreased survival, cycling, and trafficking capacity. TFH cells exhibited a distinct gene profile that was markedly altered by SIV infection. TFH cells were infected by SIV; yet, in some animals, these cells actually accumulated during chronic SIV infection. Generalized immune activation and increased IL-6 production helped drive TFH differentiation during SIV infection. Accumulation of TFH cells was associated with increased frequency of activated germinal center B cells and SIV-specific antibodies. Therefore, chronic SIV does not disturb the ability of TFH cells to help B cell maturation and production of SIV-specific immunoglobulins.

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Medicine, Research & Experimental
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