Journal article
CD8(+) Cell Depletion of SHIV89.6P-Infected Macaques Induces CD4(+) T Cell Proliferation that Contributes to Increased Viral Loads
The Journal of immunology (1950), v 183(8), pp 5006-5012
15 Oct 2009
PMID: 19786539
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Previous studies have shown that depletion of CD8(+) cells during acute and chronic simian immunodeficiency virus (SIV) infection leads to increased viral replication, morbidity, and mortality, which have been attributed to loss of CD8(+) T cell-mediated control of SIV. However, these studies did not exclude that CD8(+) cell depletion increased homeostatic proliferation of CD4(+) T cells, resulting in increased viral targets and, therefore, viral rebound. Chronically SHIV89.6P-infected cynomolgus macaques were CD8(+) cell-depleted, and the frequency, cell number, and phenotype of CD4(+) T cells and viral infection were examined using flow cytometry and quantitative real-time PCR. The frequency and number of Ki-67-expressing CD4(+) T cells were increased with CD8(+) cell depletion. This proliferation of CD4(+) T cells occurred even in animals with no rebound of viral loads. Most of the proliferating cells were effector memory CD4(+) T cells. Plasma simian HIV (SHIV) RNA copies positively correlated with proliferating CD4(+) T cells and SHIV DNA copies in Ki-67(+) CD4(+) T cells. Although this study does not exclude an important role for virus-specific CD8(+) T cells in SIV and SHIV infection, our data suggest that homeostatic proliferation is an important contributor to increases in plasma viremia that follow CD8(+) cell depletion. The Journal of Immunology, 2009,183: 5006-5012.
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Details
- Title
- CD8(+) Cell Depletion of SHIV89.6P-Infected Macaques Induces CD4(+) T Cell Proliferation that Contributes to Increased Viral Loads
- Creators
- Yvonne M. Mueller - Drexel UniversityDuc H. Do - Drexel UniversityJean D. Boyer - Supreme Council Of HealthMuhamuda Kader - Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USAJoseph J. Mattapallil - Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USAMark G. Lewis - BioqualDavid B. Weiner - Supreme Council Of HealthPeter D. Katsikis - Drexel Univ, Coll Med, Dept Microbiol & Immunol, Philadelphia, PA 19129 USA
- Publication Details
- The Journal of immunology (1950), v 183(8), pp 5006-5012
- Publisher
- American Association of Immunologists
- Number of pages
- 7
- Grant note
- R21DE018339 / NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR) National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01 AI62437; R01 AI46719; R01 A1-071886; K22 AI07812; R21 DE018339 / National Institutes of Science; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA K22AI071812 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000270830300025
- Scopus ID
- 2-s2.0-77954123356
- Other Identifier
- 991019339699504721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Immunology