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Journal article
CD8+ T-Cell Mediated Control of HIV-1 in a Unique Cohort With Low Viral Loads
Frontiers in microbiology, v 12, pp 670016-670016
28 May 2021
PMID: 34122382
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A unique population of HIV-1 infected individuals can control infection without antiretroviral therapy. These individuals fall into a myriad of categories based on the degree of control (low or undetectable viral load), the durability of control over time and the underlying mechanism (i.e., possession of protective HLA alleles or the absence of critical cell surface receptors). In this study, we examine a cohort of HIV-1 infected individuals with a documented history of sustained low viral loads in the absence of therapy. Through
in vitro
analyses of cells from these individuals, we have determined that infected individuals with naturally low viral loads are capable of controlling spreading infection
in vitro
in a CD8
+
T-cell dependent manner. This control is lost when viral load is suppressed by antiretroviral therapy and correlates with a clinical CD4:CD8 ratio of <1. Our results support the conclusion that HIV-1 controllers with low, but detectable viral loads may be controlling the virus due to an effective CD8
+
T-cell response. Understanding the mechanisms of control in these subjects may provide valuable understanding that could be applied to induce a functional cure in standard progressors.
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Details
- Title
- CD8+ T-Cell Mediated Control of HIV-1 in a Unique Cohort With Low Viral Loads
- Creators
- Amber D. Jones - Department of Biological Sciences, University of the Sciences, Philadelphia, PA, United States.Svetlana Khakhina - Department of Biological Sciences, University of the Sciences, Philadelphia, PA, United States.Tara Jaison - Department of Biological Sciences, University of the Sciences, Philadelphia, PA, United States.Erin Santos - The Smith Center for Infectious Diseases and Urban Health, West Orange, NJ, United States.Stephen Smith - Orange (Belgium)Zachary A. Klase - Drexel University
- Publication Details
- Frontiers in microbiology, v 12, pp 670016-670016
- Publisher
- Frontiers Media S.A
- Grant note
- DP2 DA044550-01 / National Institute on Drug Abuse
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology; Obstetrics and Gynecology
- Web of Science ID
- WOS:000659679400001
- Scopus ID
- 2-s2.0-85107550532
- Other Identifier
- 991019167431404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Microbiology