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https://journals.lww.com/jaids/fulltext/2013/05010/cd8__t_cell_activation_in_hiv_1_infected_patients.14.aspx
Accepted (AM)Open Access (License Unspecified), Open
Journal article
CD8+ T-cell Activation in HIV-1-Infected Patients Experiencing Transient Low-level Viremia During Antiretroviral Therapy
Journal of acquired immune deficiency syndromes (1999), v 63(1), pp 101-104
01 May 2013
PMID: 23392463
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Transient low-level viremia of 50–400 HIV RNA copies/mL (TLLV) is common during antiretroviral therapy, but its pathogenesis, consequences and optimal management are unclear. Heightened immune activation is associated with detrimental outcomes, including impaired CD4+ T-cell reconstitution. Using CD38/HLA-DR expression on CD8+ T-cells measured in two large studies, we determined associations between TLLV and immune activation levels before, during, and after TLLV. We found that TLLV does not significantly change CD8+ T-cell activation, and that higher CD8+ T-cell activation during viral suppression <50 copies/mL is associated with a modest increase in the risk of a subsequent TLLV.
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Details
- Title
- CD8+ T-cell Activation in HIV-1-Infected Patients Experiencing Transient Low-level Viremia During Antiretroviral Therapy
- Creators
- Babafemi Taiwo - Northwestern UniversityPeter W. Hunt - University of California, San FranciscoRajesh T. Gandhi - Harvard UniversityAndrew Ellingson - Harvard UniversityMatthew McKenna - Harvard UniversityJeffrey M. Jacobson - Drexel UniversityBarbara Gripshover - Case Western Reserve UniversityRonald J. Bosch - Harvard University
- Publication Details
- Journal of acquired immune deficiency syndromes (1999), v 63(1), pp 101-104
- Publisher
- Lippincott
- Grant note
- U01 AI068636 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID U01 AI068634 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000319112200023
- Scopus ID
- 2-s2.0-84876286480
- Other Identifier
- 991019335318004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases