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CD8 T cell responses to influenza virus infection in aged mice
Journal article   Open access   Peer reviewed

CD8 T cell responses to influenza virus infection in aged mice

Jiu Jiang, Erin M Fisher and Donna M Murasko
Ageing research reviews, v 10(4), pp 422-427
Sep 2011
DOI: https://doi.org/10.1016/j.arr.2011.02.001
PMID: 21315186
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1016/j.arr.2011.02.001View
Published, Version of Record (VoR) Open

Abstract

Orthomyxoviridae Infections - therapy Dendritic Cells - immunology Humans Orthomyxoviridae - immunology Aging - immunology Animals CD8-Positive T-Lymphocytes - virology Influenza, Human - virology Mice CD8-Positive T-Lymphocytes - immunology Dendritic Cells - virology Influenza, Human - therapy Orthomyxoviridae Infections - virology Orthomyxoviridae Infections - immunology Influenza, Human - immunology
Influenza is one of the most common infectious diseases afflicting humans, particularly the elderly. The murine model has been widely employed for investigation of immunity to influenza virus infection. In this paper, we review the recent advances in understanding the diminished CD8 T cell immune response to influenza virus infection in aged mice. Possible mechanisms of impaired CD8 T cell responses with aging are addressed, including: (1) the role of dendritic cells (DCs); (2) the effect of age-associated changes in the T cell repertoire; and (3) the interactions with CD4 T cells, including T regulatory (Treg) cells and CD4 T helper cells. The aged murine model of the CD8 T cell response to influenza virus is helping to elucidate the mechanisms of immunosenescence which can lead to therapeutic improvements in the primary CD8 T cell response to new infections, as well as the development of new strategies for immunization to prevent influenza in the elderly.

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Web of Science research areas
Cell Biology
Geriatrics & Gerontology
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