Journal article
CD9-mediated costimulation of TCR-triggered naive T cells leads to activation followed by apoptosis
The Journal of immunology (1950), v 159(8), pp 3799-3807
15 Oct 1997
PMID: 9378967
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The induction of full activation or death in TCR-triggered T cells depends largely on whether appropriate costimulatory signals are provided. In this study, we show that the costimulation of CD9 on naive T cells during TCR stimulation results in transient, albeit potent, activation followed by apoptosis, rather than full activation. Anti-CD9 mAb synergized with suboptimal doses of anti-CD3 mAb in inducing T cell activation. [H-3]TdR incorporation determined 2 days after CD9 costimulation was as potent as that induced by CD28 costimulation. In contrast to progressive T cell proliferation induced by CD28 costimulation, CD9 costimulation led to the induction of apoptosis of once-activated T cells. Although IL-2R expression was induced significantly earlier and to a greater degree after CD9 costimulation than after CD28 costimulation, CD9 costimulation only transiently produced a small amount of IL-2 and induced apparently low levels of bcl-x(L) compared with those observed in CD28 costimulation. Addition of rIL-2 to cultures of CD9 costimulation induced strikingly enhanced expression of bcl proteins, especially of bcl-x(L), and protected TCR-stimulated T cells from apoptosis. These data indicate that CD9-mediated costimulation of TCR-triggered naive T cells leads to activation followed by apoptosis as the result of failure to generate a positive signal for sufficient levels of IL-2 production.
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Details
- Title
- CD9-mediated costimulation of TCR-triggered naive T cells leads to activation followed by apoptosis
- Creators
- X G Tai - The University of OsakaK ToyookaY YashiroR AbeC S ParkT HamaokaM KobayashiS NebenH Fujiwara
- Publication Details
- The Journal of immunology (1950), v 159(8), pp 3799-3807
- Publisher
- American Association of Immunologists
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:A1997XZ99400016
- Scopus ID
- 2-s2.0-0031572514
- Other Identifier
- 991020111299504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology