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CO interact with intracellular [H+] with and without CO2-HCO3- in the cat carotid chemosensory discharge
Journal article   Open access   Peer reviewed

CO interact with intracellular [H+] with and without CO2-HCO3- in the cat carotid chemosensory discharge

S Osanai, C Rozanov, A Mokashi, D G Buerk and S Lahiri
Brain research, v 764(1-2), pp 221-224
01 Aug 1997
DOI: https://doi.org/10.1016/S0006-8993(97)00495-2
PMID: 9295213
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1016/s0006-8993(97)00495-2View
Published, Version of Record (VoR)CC BY-NC-ND V4.0,  Open

Abstract

Animals Bicarbonates - metabolism Carbon Dioxide - metabolism Carbon Monoxide - metabolism Carotid Body - metabolism Cats Dose-Response Relationship, Drug Electrophysiology Female Hydrogen - metabolism In Vitro Techniques Male Proton Pumps - physiology
To test the hypothesis whether CO2-HCO3- buffer is essential for the expression of chemoreception and to distinguish between pHi and pHo interaction with pCO in the carotid chemosensory response, we superfused-perfused in vitro cat carotid bodies using HEPES-Tyrode's solution with and without CO2-HCO3-, and compared the responses at the same pHo in the absence and presence of light. In the absence of light, pCO (> 138 Torr) stimulated the carotid body chemoreceptors in CO2-HCO3- buffer at pHo of 7.40, whereas pCO (69-550 Torr) did not stimulate the neural discharge in HEPES buffer at the pHo of 7.4-7.1 but did so below pHo 7.1. In the presence of light, all the responses were diminished proportionately.

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