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Journal article
CORRELATION OF CHROMOSOME DAMAGE AND PROMOTER METHYLATION STATUS OF THE DNA REPAIR GENES MGMT AND HMLH1 IN CHINESE VINYL CHLORIDE MONOMER (VCM)-EXPOSED WORKERS
International journal of occupational medicine and environmental health, v 26(1), pp 173-182
01 Jan 2013
PMID: 23412991
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To explore the association of the methylation status of MGMT and hMLH1 with chromosome damage induced by vinyl chloride monomer (VCM).
Methylation of MGMT and hMLH1 was measured in 101 VCM-exposed workers by methylation-specific PCR. Chromosome damage in peripheral blood lymphocytes was measured by the cytokinesis-block micronucleus assay. The subjects were divided into chromosome damaged and non-damaged groups based on the normal reference value of micronuclei frequencies determined for two control groups.
MGMT promoter methylation was detectable in 5 out of 49 chromosome damaged subjects, but not in the chromosome non-damaged subjects; there was a significant difference in MGMT methylation between the two groups (p < 0.05).
We detected aberrant promoter methylation of MGMT in a small number of chromosome damaged VCM-exposed workers, but not in the chromosome non-damaged subjects. This preliminary observation warrants further investigation in a larger study.
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Details
- Title
- CORRELATION OF CHROMOSOME DAMAGE AND PROMOTER METHYLATION STATUS OF THE DNA REPAIR GENES MGMT AND HMLH1 IN CHINESE VINYL CHLORIDE MONOMER (VCM)-EXPOSED WORKERS
- Creators
- Fen Wu - Department of Occupational Health and Toxicology, School of Public Health, Fudan University and Key Laboratory of Public Health and Safety of the Ministry of Education of China, Shanghai, ChinaJing Liu - School of Public Health, Fudan University and Key Laboratory of Public Health and Safety of the Ministry of Education of ChinaYu-Lan Qiu - Shanxi Medical UniversityWei Wang - Zhengzhou UniversityShou-Min Zhu - School of Public Health, Fudan University and Key Laboratory of Public Health and Safety of the Ministry of Education of ChinaPin Sun - School of Public Health, Fudan University and Key Laboratory of Public Health and Safety of the Ministry of Education of ChinaWen-Bin Miao - Fudan Univ, Dept Occupat Hlth & Toxicol, Sch Publ Hlth, Shanghai 200032, Peoples R ChinaYong-Liang Li - Univ Illinois, Sch Publ Hlth, Chicago, IL USAPaul W. Brandt-Rauf - University of Illinois ChicagoZhao-Lin Xia - School of Public Health, Fudan University and Key Laboratory of Public Health and Safety of the Ministry of Education of China
- Publication Details
- International journal of occupational medicine and environmental health, v 26(1), pp 173-182
- Publisher
- VERSITA
- Number of pages
- 10
- Grant note
- NSFC 30070650; 30671740 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) 08GWD12; 08GWZX0402 / Shanghai Bureau of Public Health 20100471583 / China Postdoctoral Science Foundation R01-OH04192; P30-ES09089 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01OH004192 / NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA; National Institute for Occupational Safety & Health (NIOSH) P30ES009089 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000317428800017
- Scopus ID
- 2-s2.0-84876104755
- Other Identifier
- 991019176644204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health