Journal article
CP-94,253: a selective serotonin1B (5-HT1B) agonist that promotes satiety
Psychopharmacology, v 131(3), pp 264-270
Jun 1997
PMID: 9203237
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The selective 5-HT1B agonist CP-94,253 (3-(1,2,5,6-tetrahydro-4-pyridyl)-5-propoxypyrrolo[3,2-b] pyridine) (5–40 μmol/kg) reduced the intake of both pellets and a 10% solution of sucrose (ID50 = 12.5 and 22.8 μmol/kg, respectively) in mildly deprived rats. Time-sampled observations revealed that CP-94,253 terminated feeding earlier, without disrupting the continuity of feeding. CP-94,253 increased standing but did not promote resting during satiation. Microstructural analysis of licking indicated that CP-94,253 decreased the frequency, but not the size, of bursts and clusters of licks without altering oral motor efficiency. The peripherally acting 5-HT1B agonist, CP-93,129 (3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one) had no effect on food intake. These results imply that CP-94,253 probes a role for central 5-HT1B receptors in the regulation of meal size and duration, but that recruitment of other 5-HT receptor subtypes may be needed for the full expression of satiety.
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Details
- Title
- CP-94,253: a selective serotonin1B (5-HT1B) agonist that promotes satiety
- Creators
- Michelle D Lee - Department of Pharmacology, MCP, ? Hahnemann School of Medicine, Allegheny University of the Health Sciences, 3200 Henry Avenue, Philadelphia, PA 19129, USA USK. J Simansky - Department of Pharmacology, MCP, ? Hahnemann School of Medicine, Allegheny University of the Health Sciences, 3200 Henry Avenue, Philadelphia, PA 19129, USA US
- Publication Details
- Psychopharmacology, v 131(3), pp 264-270
- Publisher
- Springer-Verlag; Berlin/Heidelberg
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1997XG10900008
- Scopus ID
- 2-s2.0-0030848158
- Other Identifier
- 991014877949304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences
- Pharmacology & Pharmacy
- Psychiatry