Journal article
CSF-ACE activity in probable CNS neurosarcoidosis
Sarcoidosis, vasculitis, and diffuse lung diseases, v 19(3), pp 191-197
01 Oct 2002
PMID: 12405488
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
OBJECTIVETo redefine the utility of CSF-ACE as a selective indicator of probable CNS neurosarcoidosis.METHODSThe diagnosis of probable CNS neurosarcoidosis required: (a) biopsy evidence of systemic sarcoidosis, (b) cortical, brainstem, and/or spinal cord deficits, (c) enhancing lesions on brain and/or spinal cord MRI, and (d) exclusion of other etiologies which could account for the neurological deficits. Radioassay measurement of CSF-ACE activity was performed in 11 patients who met our criteria for probable CNS neurosarcoidosis and 207 control patients.RESULTSThe M +/- SD for CSF-ACE activity was significantly higher (p < 0.05) for the 11 probable CNS neurosarcoidosis patients (9.5 +/- 6.9 nmol/mL/min) than for the control patients (2.9 +/- 2.7 nmol/mL/min). The optimal CSF-ACE activity discriminator value was 8 nmol/mL/min. At this value, the sensitivity and specificity of CSF-ACE activity was 55% and 94%, respectively.CONCLUSIONSCSF-ACE activity is a useful biochemical marker of probable CNS neurosarcoidosis when brain and/or spinal cord MRI show diffuse enhancing lesions.
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Details
- Title
- CSF-ACE activity in probable CNS neurosarcoidosis
- Creators
- Albert J TahmoushMary S AmirWilliam W ConnorJames K FarrySevastian DidatoAlice Ulhoa-CintraJennifer M VasasRobert J SchwartzmanHarold L IsraelHerbert Patrick
- Publication Details
- Sarcoidosis, vasculitis, and diffuse lung diseases, v 19(3), pp 191-197
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000178653800006
- Scopus ID
- 2-s2.0-0036790686
- Other Identifier
- 991019168493404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Respiratory System