Journal article
CT-guided transthoracic needle aspiration biopsy of subsolid lung lesions
Journal of vascular and interventional radiology, v 25(3), pp 340-346.e1
01 Mar 2014
PMID: 24581458
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To assess the diagnostic performance of computed tomography (CT)-guided transthoracic needle aspiration biopsy (TNAB) in the evaluation of persistent subsolid lung lesions.
A retrospective review of all CT-guided TNABs performed at a single institution from January 2002 to November 2012 was conducted to identify patients with persistent subsolid lung lesions. The diagnostic performance of CT-guided TNAB was assessed through comparison of cytologic diagnoses with core needle biopsy, surgical resection, or imaging and clinical follow-up. The cytologic, histologic, and imaging features of each lesion were characterized, and CT-guided TNAB complications were recorded.
In 32 patients, a diagnosis of benign or malignant disease was identified through evaluation of pathologic or follow-up data. There were 18 men and 14 women, with a mean age of 67.1 years ± 9.6 (range, 52-86 y). The mean lesion diameter was 21 mm ± 11 (range, 8-62 mm). A final diagnosis of malignancy was made in 28 cases (87.5%); four benign lesions were also diagnosed. The overall sensitivity of CT-guided TNAB in the evaluation of these lesions was 89.2%, and the specificity and positive predictive value were 100%. Two pneumothoraces (6.3%) were identified.
Among patients with subsolid lung lesions, CT-guided TNAB is safe and shows high sensitivity. The high specificity and positive predictive value of the procedure allow for definitive treatment decisions to be made for most patients.
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Details
- Title
- CT-guided transthoracic needle aspiration biopsy of subsolid lung lesions
- Creators
- Aaron W P Maxwell - University of VermontJeffrey S Klein - Allen HospitalKossivi Dantey - Allen HospitalSharon L Mount - Allen HospitalKelly J Butnor - University of Vermont Medical CenterGladwyn Leiman - Allen Hospital
- Publication Details
- Journal of vascular and interventional radiology, v 25(3), pp 340-346.e1
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:000333067400003
- Scopus ID
- 2-s2.0-84896840411
- Other Identifier
- 991021930444604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Peripheral Vascular Disease
- Radiology, Nuclear Medicine & Medical Imaging