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https://eprints.qut.edu.au/30260/1/CTA1-DD_is_an_effective_adjuvant_for_targeting_anti-chlamydial_immunity_to_the_murine_genital_mucosa.pdf
SubmittedOpen Access (License Unspecified), Open
Journal article
CTA1-DD is an effective adjuvant for targeting anti-chlamydial immunity to the murine genital mucosa
Journal of reproductive immunology, v 81(1), pp 34-38
2009
PMID: 19501917
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Chlamydia trachomatis is a significant human pathogen with potentially severe disease sequelae in the genital tract, including infertility. A successful vaccine will need to effectively target immunity to the genital mucosa. Intranasal immunisation with cholera toxin (CT) can target immunity to the genital tract, but has the potential to cause neurological side effects. CTA1-DD is a non-toxic potent mucosal adjuvant which combines the enzymatic properties of CT, with a B cell targeting moiety. Here, we demonstrate that intranasal immunisation with CTA1-DD and chlamydial Major Outer Membrane Protein (MOMP) results in the induction of neutralising systemic and mucosal antibodies, and reduces the level of chlamydial shedding following intravaginal challenge with
Chlamydia muridarum. Thus, CTA1-DD is an effective adjuvant for vaccine development against
Chlamydia trachomatis, and possibly also a range of other genital pathogens.
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Details
- Title
- CTA1-DD is an effective adjuvant for targeting anti-chlamydial immunity to the murine genital mucosa
- Creators
- Kelly A. Cunningham - Queensland University of TechnologyAlison J. Carey - Queensland University of TechnologyNils Lycke - Vaccine Research CenterPeter Timms - Queensland University of TechnologyKenneth W. Beagley - Queensland University of TechnologySahlgrenska akademin
- Publication Details
- Journal of reproductive immunology, v 81(1), pp 34-38
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; College of Medicine; Drexel University
- Web of Science ID
- WOS:000268607000005
- Scopus ID
- 2-s2.0-67649743425
- Other Identifier
- 991020100208404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology
- Reproductive Biology