Journal article
CYP2E1 mRNA Expression, Genetic Polymorphisms in Peripheral Blood Lymphocytes and Liver Abnormalities in Chinese VCM-Exposed Workers
International journal of occupational medicine and environmental health, v 21(2), pp 141-146
01 Jan 2008
PMID: 18715838
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: To study the relationship between expression of cytochrome P4502E1 (CYP2E1) in human lymphocytes, variant CYP2E1 genotype, exposure to vinyl chloride monomer (VCM), and liver abnormalities in VCM-exposed workers. Methods: A case-control study was performed on 90 male occupationally exposed workers and 42 matched male nonexposed controls. Data were collected based on health surveillance, workplace investigation and questionnaire Survey. Total RNA and DNA were isolated from peripheral blood lymphocytes, and CYP2E1 mRNA expression was determined using RT-PCR, and the presence of CYP2E1 polymorphisms was identified based on PCR-RFLP. Results: The mRNA expression of CYP2E1 in exposed workers (0.89±0.46) was significantly higher than in nonexposed controls (0.61±0.35) (P < 0.01). Logistic regression analysis demonstrated a statistically significant association between CYP2E1 mRNA expression levels and liver abnormalities in the VCM-exposed workers (OR = 3.66, P < 0.05). The genotype frequency for CYP2E1 variants among VCM-exposed workers was not significantly different between workers with liver abnormalities and those without. Conclusions: Liver abnormalities in subjects exposed to VCM are positively associated with expression of peripheral blood lymphocyte mRNA, which is significantly increased in exposed workers compared to nonexposed controls. Therefore, CYP2E1 mRNA levels may be useful for health surveillance and protection of VCM-exposed workers.
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Details
- Title
- CYP2E1 mRNA Expression, Genetic Polymorphisms in Peripheral Blood Lymphocytes and Liver Abnormalities in Chinese VCM-Exposed Workers
- Creators
- Ai-Hong Wang - Fudan UniversityShou-Min Zhu - Fudan UniversityYu-Lan Qiu - Fudan UniversityRen Zhu - Fudan UniversityYa-Bin Qu - Fudan UniversityYong-Liang Li - Columbia UniversityPaul Brandt-Rauf - Columbia UniversityZhao-Lin Xia - Fudan University
- Publication Details
- International journal of occupational medicine and environmental health, v 21(2), pp 141-146
- Publisher
- Versita
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:000259249000004
- Scopus ID
- 2-s2.0-50049097289
- Other Identifier
- 991019323762404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health