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Calcium and magnesium ATPase activities in women with varying BMIs
Journal article   Open access   Peer reviewed

Calcium and magnesium ATPase activities in women with varying BMIs

Jennifer A Nasser, Sami A Hashim and Paul A Lachance
Obesity research, v 12(11), pp 1844-1850
Nov 2004
DOI: https://doi.org/10.1038/oby.2004.229
PMID: 15601981
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1038/oby.2004.229View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

Body Mass Index Body Weight Humans Middle Aged Erythrocyte Membrane - enzymology Calcium - blood Regression Analysis Adult Body Height Ca(2+) Mg(2+)-ATPase - blood Female Calcium-Transporting ATPases - blood Obesity - enzymology
Intracellular calcium (Ca) is increased in obese humans, and magnesium (Mg)-ATPase activity is increased in monosodium glutamate-induced obese rats. The aims of this study were to test the hypotheses that Ca-ATPase activity is negatively correlated with BMI, and that Mg-ATPase activity is positively correlated with BMI and Ca-ATPase activity in obese women. Thirty healthy adult women, with BMIs of 20 to 40, donated a single sample of whole blood and were interviewed as to medical history and family history of obesity. Erythrocyte membranes were isolated and assayed for Ca-ATPase and Mg-ATPase. Weight and height were self-reported. Regression analysis was used to determine relationship between BMI and enzyme activity. Family history of obesity served as a covariant. Ca-ATPase was negatively correlated with increasing BMI (r = - 0.38, p = 0.02). The relationship between BMI and Ca-ATPase remained valid after controlling for family history of obesity (r = -0.36, p = 0.03). There was a positive correlation between Mg-ATPase activity and Ca-ATPase (r = 0.42, p = 0.024), and this relationship remained valid after controlling for BMI and family history of obesity (r = 0.41, p = 0.03). Ca-ATPase activity decreases as BMI increases. Decreased ATPase activity may contribute to increased intracellular calcium, previously reported in obese persons. Further studies are needed to determine whether a drop in Ca-ATPase activity can serve as a marker for the development of obesity.

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5 citations in Web of Science
8 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Endocrinology & Metabolism
Nutrition & Dietetics
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