Journal article
Calcium-induced Ca2+ release from sarcoplasmic reticulum of pigs susceptible to malignant hyperthermia: The effects of halothane and dantrolene
FEBS letters, v 161(1), pp 103-107
05 Sep 1983
PMID: 6884519
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Calcium-induced calcium release and halothane-induced calcium release from pig sarcoplasmic reticulum (SR) were studied. The SR prepared from pig susceptible to malignant hyperthermia (MH) was shown to release calcium at a much lower level of calcium content than in normal pig SR. The concentration above which halothane can release calcium is 40 μM for both MH-SR and normal SR, although the latter required a high calcium content to demonstrate the calcium release. Dantrolene was shown to inhibit the halothane-induced calcium release. Results suggests that SR plays an importnat role in pathogenesis of MH.
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Details
- Title
- Calcium-induced Ca2+ release from sarcoplasmic reticulum of pigs susceptible to malignant hyperthermia: The effects of halothane and dantrolene
- Creators
- S. Tsuyoshi Ohnishi - Department of Hematology and Medical Oncology, Hahnemann University School of Medicine, Philadelphia PA 19102, USAStuart Taylor - University of RochesterGerald A. Gronert - Mayo ClinicSuzanne L Taylor - Advanced Role Master of Science in Nursing (MSN)
- Publication Details
- FEBS letters, v 161(1), pp 103-107
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Advanced Role Master of Science in Nursing (MSN)
- Web of Science ID
- WOS:A1983RH92700021
- Scopus ID
- 2-s2.0-0020644781
- Other Identifier
- 991019183957404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics
- Cell Biology