Journal article
Calcium phosphorus metabolism in dialysis patients with and without mitral anular calcium
The American journal of cardiology, v 51(3), pp 497-500
1983
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Abstract
To test the hypothesis that accelerated metastatic calcification in the mitral anulus results from abnormalities in calcium phosphorus and parathyroid hormone, 10 patients with end-stage renal disease having echocardiographically proven mitral anular calcium (MAC) (Group I) and 20 patients without MAC (Group II) were evaluated over 12 consecutive months. Serum levels of total calcium, phosphorus, intact and carboxyl-terminal parathyroid hormone, serum ionized calcium, and total calcium-phosphorus product were compared for both groups. In addition, other variables such as sex, supine systolic and diastolic blood pressure, age, duration of hemodialysis, type of renal disease, and diabetes also were compared in both groups.
Although both groups had elevated intact and carboxyl-terminal parathyroid hormone levels. Group I did not differ significantly from Group II. Total serum calcium levels were within normal limits in both groups and were not significantly different. However, the serum ionized calcium level was significantly higher in Group I with MAC versus Group II without MAC (p <0.05). The serum phosphorus level and calcium phosphorus product were significantly higher in the group with MAC compared to the group without MAC (p <0.01 and p <0.001, respectively). No significant differences were found in the other clinical variables analyzed.
It is concluded that MAC in patients with chronic renal failure occurs in the setting of secondary hyperparathyroidism. However, it is found more often in patients with increased ionized calcium and serum phosphorus levels and significantly higher calcium-phosphorus product levels. In chronic renal failure, MAC does not appear to be the result of a degenerative process and high ventricular systolic pressure as has been previously described.
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Details
- Title
- Calcium phosphorus metabolism in dialysis patients with and without mitral anular calcium
- Creators
- Pasquale F. Nestico - Cardiovascular Institute of the SouthNicholas L. DePace - Cardiovascular Institute of the SouthMorris N. Kotler - Cardiovascular Institute of the SouthLeslie I. Rose - Cardiovascular Institute of the SouthJoseph H. Brezin - Cardiovascular Institute of the SouthCharles Swartz - Cardiovascular Institute of the SouthGary S. Mintz - Cardiovascular Institute of the SouthAllan B. Schwartz - Cardiovascular Institute of the South
- Publication Details
- The American journal of cardiology, v 51(3), pp 497-500
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate); Nephrology (and Hypertension)
- Web of Science ID
- WOS:A1983QB10100024
- Scopus ID
- 2-s2.0-0020659529
- Other Identifier
- 991019183938304721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems