Journal article
Calcium release-activated calcium channels and pain
Cell calcium (Edinburgh), v 74, pp 180-185
Sep 2018
PMID: 30096536
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Calcium release-activated calcium (CRAC) channels are unique among ion channels that are activated in response to depletion of intracellular calcium stores and are highly permeable to Ca
compared to other cations. CRAC channels mediate an important calcium signal for a wide variety of cell types and are well studied in the immune system. They have been implicated in a number of disorders such as immunodeficiency, musculosketal disorders and cancer. There is growing evidence showing that CRAC channels are expressed in the nervous system and are involved in pathological conditions including pain. This review summarizes the expression, distribution, and function of the CRAC channel family in the dorsal root ganglion, spinal cord and some brain regions, and discusses their functional significance in neurons and glial cells and involvement in nociception and chronic pain. Although further studies are needed to understand how these channels are activated under physiological conditions, the recent findings indicate that the CRAC channel Orai1 is an important player in pain modulation and could represent a new target for pathological pain.
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Details
- Title
- Calcium release-activated calcium channels and pain
- Creators
- Yixiao Mei - Rutgers, The State University of New JerseyJames E Barrett - Drexel UniversityHuijuan Hu - Rutgers, The State University of New Jersey
- Publication Details
- Cell calcium (Edinburgh), v 74, pp 180-185
- Publisher
- Elsevier
- Grant note
- R01 NS087033 / NINDS NIH HHS R21 NS077330 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000444525500019
- Scopus ID
- 2-s2.0-85051012151
- Other Identifier
- 991019169561404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Physiology