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Calmodulin modulates prolactin secretion in vitro: Studies with calmodulin containing liposomes
Journal article   Peer reviewed

Calmodulin modulates prolactin secretion in vitro: Studies with calmodulin containing liposomes

Gennaro Schettini, Tullio Florio, Olimpia Meucci, Elisa Landolfi, Michael J. Cronin and Robert M. MacLeod
Life sciences (1973), v 41(22), pp 2437-2444
1987
DOI: https://doi.org/10.1016/0024-3205(87)90669-2
PMID: 2824954
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

The control of prolactin secretion by Ca +++calmodulin and cyclic AMP was studied. Ca ++ ionophore A23187 stimulated both cyclic AMP accumulation and prolactin release by primary culture of anterior pituitary cells in vitro. The increase of cyclic AMP formation by A23187 preceded that of prolactin release. To test the calmodulin involvment in these processes we used either selective calmodulin antagonist, the naphtalene sulphonamide derivative W7, or calmodulin containing liposomes. W7 dose dependently inhibited both basal or A23187 stimulated cyclic AMP accumulation and prolactin secretion. Insertion of Ca +++ calmodulin within the cells stimulated prolactin secretion without modifying cyclic AMP accumulation. W7 inhibited the Ca +++calmodulin containing liposomes stimulation of prolactin release. These results suggest that calmodulin partecipates to the process of prolactin release.

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5 citations in Web of Science
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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Medicine, Research & Experimental
Pharmacology & Pharmacy
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