Journal article
Caloric restriction augments radiation efficacy in breast cancer
Cell cycle (Georgetown, Tex.), v 12(12), pp 1955-1963
15 Jun 2013
PMID: 23708519
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Dietary modification such as caloric restriction (CR) has been shown to decrease tumor initiation and progression. We sought to determine if nutrient restriction could be used as a novel therapeutic intervention to enhance cytotoxic therapies such as radiation (IR) and alter the molecular profile of triple-negative breast cancer (TNBC), which displays a poor prognosis. In two murine models of TNBC, significant tumor regression is noted with IR or diet modification, and a greater regression is observed combining diet modification with IR. Two methods of diet modification were compared, and it was found that a daily 30% reduction in total calories provided more significant tumor regression than alternate day feeding. At the molecular level, tumors treated with CR and IR showed less proliferation and more apoptosis. cDNA array analysis demonstrated the IGF-1R pathway plays a key role in achieving this physiologic response, and multiple members of the IGF-1R pathway including IGF-1R, IRS, PIK3ca and mTOR were found to be downregulated. The innovative use of CR as a novel therapeutic option has the potential to change the biology of tumors and enhance the opportunity for clinical benefit in the treatment of patients with TNBC.
Metrics
Details
- Title
- Caloric restriction augments radiation efficacy in breast cancer
- Creators
- Anthony D. Saleh - National Institutes of HealthBrittany A. Simone - Thomas Jefferson UniversityJuan Palazzo - Thomas Jefferson UniversityJason E. Savage - National Institutes of HealthYuri SanoTu Dan - Sidney Kimmel Cancer CenterLianjin Jin - Thomas Jefferson UniversityColin E. Champ - Thomas Jefferson UniversityShuping Zhao - National Institutes of HealthMeng Lim - Thomas Jefferson UniversityFrederica SotgiaKevin Camphausen - National Institutes of HealthRichard G. Pestell - Thomas Jefferson UniversityJames B. Mitchell - National Institutes of HealthMichael P. Lisanti - Thomas Jefferson UniversityNicole L. Simone - Thomas Jefferson University
- Publication Details
- Cell cycle (Georgetown, Tex.), v 12(12), pp 1955-1963
- Publisher
- Landes Bioscience
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000323170200027
- Scopus ID
- 2-s2.0-84879390182
- Other Identifier
- 991021897377904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology