Journal article
Can Soluble Immune Checkpoint Molecules on Exosomes Mediate Inflammation?
Journal of neuroimmune pharmacology
25 Oct 2021
PMID: 34697721
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Immune checkpoints (ICPs) are major co-signaling pathways that trigger effector functions in immune cells, with isoforms that are either membrane bound, engaging in direct cell to cell activation locally, or soluble, acting at distant sites by circulating freely or potentially via extracellular vesicles (EVs). Exosomes are small EVs secreted by a variety of cells carrying various proteins and nucleic acids. They are distributed extensively through biological fluids and have major impacts on infectious diseases, cancer, and neuroinflammation. Similarly, ICPs play key roles in a variety of disease conditions and have been extensively utilized as a prognostic tool for various cancers. Herein, we explored if the association between exosomes and ICPs could be a significant contributor of inflammation, particularly in the setting of cancer, neuroinflammation and viral infections, wherein the up regulation in both exosomal proteins and ICPs correlate with immunosuppressive effects. The detailed literature review of existing data highlights the significance and complexity of these two important pathways in mediating cancer and potentiating neuroinflammation via modulating overall immune response.
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Details
- Title
- Can Soluble Immune Checkpoint Molecules on Exosomes Mediate Inflammation?
- Creators
- Julie Joseph - Drexel UniversityBenjamin Rahmani - Drexel UniversityYonesha Cole - Drexel UniversityNeha Puttagunta - Drexel UniversityEdward Lin - Drexel UniversityZafar K. Khan - Drexel UniversityPooja Jain - Drexel University
- Publication Details
- Journal of neuroimmune pharmacology
- Publisher
- Springer Nature
- Number of pages
- 17
- Grant note
- R01 NS097147 / NIH/NINDS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; College of Medicine
- Identifiers
- 991019167128904721
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InCites Highlights
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- Web of Science research areas
- Neurosciences
- Pharmacology & Pharmacy