Journal article
Can vitamin D deficiency cause diabetes and cardiovascular diseases? Present evidence and future perspectives
Nutrition, metabolism, and cardiovascular diseases, v 22(2), pp 81-87
Feb 2012
PMID: 22265795
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Several studies have shown that vitamin D may play a role in many biochemical mechanisms in addition to bone and calcium metabolism. Recently, vitamin D has sparked widespread interest because of its involvement in the homeostasis of the cardiovascular system. Hypovitaminosis D has been associated with obesity, related to trapping in adipose tissue due to its lipophilic structure. In addition, vitamin D deficiency is associated with increased risk of cardiovascular disease (CVD) and this may be due to the relationship between low vitamin D levels and obesity, diabetes mellitus, dyslipidaemia, endothelial dysfunction and hypertension. However, although vitamin D has been identified as a potentially important marker of CVD, the mechanisms through which it might modulate cardiovascular risk are not fully understood. Given this background, in this work we summarise clinical retrospective and prospective observational studies linking vitamin D levels with cardio-metabolic risk factors and vascular outcome. Moreover, we review various randomised controlled trials (RCTs) investigating the effects of vitamin D supplementation on surrogate markers of cardiovascular risk. Considering the high prevalence of hypovitaminosis D among patients with high cardiovascular risk, vitamin D replacement therapy in this population may be warranted; however, further RCTs are urgently needed to establish when to begin vitamin D therapy, as well as to determine the dose and route and duration of administration.
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Details
- Title
- Can vitamin D deficiency cause diabetes and cardiovascular diseases? Present evidence and future perspectives
- Creators
- G. Muscogiuri - Catholic University of the Sacred HeartG.P. Sorice - Catholic University of the Sacred HeartR. Ajjan - University of LeedsT. Mezza - Catholic University of the Sacred HeartS. Pilz - Medical University of GrazA. Prioletta - Catholic University of the Sacred HeartR. Scragg - University of AucklandS.L. Volpe - Drexel UniversityM.D. Witham - University of DundeeA. Giaccari - Catholic University of the Sacred Heart
- Publication Details
- Nutrition, metabolism, and cardiovascular diseases, v 22(2), pp 81-87
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Nutrition Sciences
- Web of Science ID
- WOS:000300398300006
- Scopus ID
- 2-s2.0-84856603245
- Other Identifier
- 991019167535704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Endocrinology & Metabolism
- Nutrition & Dietetics