Journal article
Candida albicans and Candida glabrata clinical isolates exhibiting reduced echinocandin susceptibility
Antimicrobial agents and chemotherapy, v 50(8), pp 2892-2894
Aug 2006
PMID: 16870797
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A recognized hotspot for mutations conferring reduced echinocandin susceptibility (RES) is residue S645 of Candida albicans Gsc1(Fks1). We report that the mutation F641Y is associated with RES in a C. albicans isolate. The analogous Fks2 residue is mutated F to V in a Candida glabrata RES isolate; the introduction of this mutation into susceptible C. glabrata confirmed its role in RES. Y641-equivalent Fks residues were identified in intrinsically RES Fusarium species and Candida guilliermondii.
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Details
- Title
- Candida albicans and Candida glabrata clinical isolates exhibiting reduced echinocandin susceptibility
- Creators
- Santosh Katiyar - Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USAMichael PfallerThomas Edlind
- Publication Details
- Antimicrobial agents and chemotherapy, v 50(8), pp 2892-2894
- Publisher
- American Society for Microbiology (ASM); United States
- Grant note
- R01 AI047718 / NIAID NIH HHS R03 AI054289 / NIAID NIH HHS AI47718 / NIAID NIH HHS AI054289 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000239640400051
- Scopus ID
- 2-s2.0-33746922380
- Other Identifier
- 991014877720804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Microbiology
- Pharmacology & Pharmacy