Journal article
Candida glabrata Mutants Demonstrating Paradoxical Reduced Caspofungin Susceptibility but Increased Micafungin Susceptibility
Antimicrobial agents and chemotherapy, v 55(8), pp 3947-3949
Aug 2011
PMID: 21628537
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Echinocandins, including caspofungin (CSP) and micafungin (MCF), are highly active versus
Candida glabrata
(MIC of ≤0.06 μg/ml). True resistance (MIC of ≥1 μg/ml) is a rare event and strictly associated with mutations in β-1,3-glucan synthase gene
FKS1
or
FKS2
. In contrast, we show here that mutants exhibiting reduced susceptibility to CSP (CRS; MICs of 0.12 to 0.5 μg/ml) are readily selected
in vitro
and, paradoxically, demonstrate increased susceptibility to MCF (MIS) ranging from 4- to 32-fold. CRS-MIS mutants were generated from all 10
C. glabrata
strains tested and were tentatively identified within a collection of clinical isolates. Intriguingly, sequencing and gene disruption demonstrated that CRS-MIS is Fks independent.
Metrics
Details
- Title
- Candida glabrata Mutants Demonstrating Paradoxical Reduced Caspofungin Susceptibility but Increased Micafungin Susceptibility
- Creators
- Kelley R Healey - Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PennsylvaniaSantosh K Katiyar - Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PennsylvaniaMariana Castanheira - JMI Laboratories, North Liberty, IowaMichael A Pfaller - Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IowaThomas D Edlind - Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania
- Publication Details
- Antimicrobial agents and chemotherapy, v 55(8), pp 3947-3949
- Publisher
- American Society for Microbiology; 1752 N St., N.W., Washington, DC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000292733800041
- Scopus ID
- 2-s2.0-79960319993
- Other Identifier
- 991014877928904721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Microbiology
- Pharmacology & Pharmacy