Journal article
Candidate Gene Associations with the Blood Pressure Response to Aerobic Exercise Training: A Meta-Analysis
Medicine and science in sports and exercise, Vol.44(5S), pp.436-436
01 May 2012
Abstract
Aerobic exercise (AE) lowers blood pressure (BP) 5-7 mmHg among those with hypertension, but there is considerable inter-individual variability in the BP response to AE. We performed a meta-analysis to integrate the small number of studies that examined the influence of candidate genes on the BP response to AE training. Studies retrieved included an AE training intervention; human Caucasians; and BP before and after AE by genotype. Effect sizes were the standardized mean difference of post-vs. pre-exercise BP disaggregated for genotype adjusted for baseline BP differences. To explain the large heterogeneity, we categorized genotype by BP regulatory pathway. The genotype effect for DBP was weak for polymorphisms in the renin-angiotensin system [RAS, d+ = - 0.119 (95% CI = - 0.227 to - 0.010, - 0.05 mmHg] and SNS [d+ = - 0.237 (95% CI = -0.083 to - 0.391, - 0.016 mmHg].
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Details
- Title
- Candidate Gene Associations with the Blood Pressure Response to Aerobic Exercise Training: A Meta-Analysis
- Creators
- Michael BruneauTania Huedo-MedinaBlair JohnsonKara LarsonLinda Pescatello
- Publication Details
- Medicine and science in sports and exercise, Vol.44(5S), pp.436-436
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Health Sciences
- Identifiers
- 991020836363104721