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Journal article
Candidate Interneurons Mediating the Resetting of the Locomotor Rhythm by Extensor Group I Afferents in the Cat
NEUROSCIENCE, v 450, pp 96-112
01 Dec 2020
PMID: 32946952
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sensory information arising from limb movements controls the spinal locomotor circuitry to adapt the motor pattern to demands of the environment. Stimulation of extensor group (gr) I afferents during fictive locomotion in decerebrate cats prolongs the ongoing extension, and terminates ongoing flexion with an initiation of the subsequent extension, i. e. resetting to extension. Moreover, instead of the classical Ib non-reciprocal inhibition, stimulation of extensor gr I afferents produces a polysynaptic excitation in extensor motoneurons with latencies (similar to 3.5-4.0 ms) compatible with 3 interposed interneurons. We assume that some interneurons in this pathway actually belong to the rhythm-generating layer of the locomotor Central Pattern Generator (CPG), since their activity was correlated to a resetting of the rhythm. In the present work fictive locomotion was (mostly) induced by i.v. injection of nialamide followed by L-DOPA in paralyzed cats following decerebration and spinalization at C1 level. In some experiments, we extended previous observations during fictive locomotion on the emergence and locomotor state-dependence of polysynaptic excitatory postsynaptic potentials from extensor gr I afferents to ankle extensor motoneurons. However, the main focus was to record location and properties of interneurons (n = 62) that (i) were active during the extensor phase of fictive locomotion and (ii) received short-latency excitation (mono-, di- or polysynaptic) from extensor gr I afferents. We conclude that the interneurons recorded fulfill the characteristics to belong to the neuronal pathway activated by extensor gr I afferents during locomotion, and may contribute to the 'resetting to extension' as part of the locomotor CPG. (c) 2020 IBRO. Published by Elsevier Ltd. All rights reserved.
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Details
- Title
- Candidate Interneurons Mediating the Resetting of the Locomotor Rhythm by Extensor Group I Afferents in the Cat
- Publication Details
- NEUROSCIENCE, v 450, pp 96-112
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD; OXFORD
- Number of pages
- 0
- Grant note
- We gratefully thank Jorge Calvo and Alejandro Carapia (Mexico) and Lillian Grondahl (Denmark) for technical assistance. We acknowledge the following funding sources: CINVESTAV (J.N.Q. and H.H.), Mexico, and Danish Medical Research Council (H.H.), Denmark. K.S. was supported by EU FP6 Marie Curie Fellowship.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000595588700009
- Scopus ID
- 2-s2.0-85092108941
- Other Identifier
- 991021860684804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences