Journal article
Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A
Psychiatric genetics, v 19(3)
01 Jun 2009
PMID: 19352218
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives Attention-deficit hyperactivity disorder (ADHD) is a highly heritable, common developmental disorder. Although a few confirmed associations have emerged from candidate gene studies, these have shown the same limitations that have become evident in the study of other complex diseases, often with inconsistent and nonreplicated results across different studies.
Methods In this report, 27 ADHD candidate genes were explored in greater depth using high-density tag single nucleotide polymorphism (SNP) genotyping. Association with 557 SNPs was tested using the transmission disequilibrium test in 270 nuclear pedigrees selected from an ongoing ADHD genetic study that includes all disease subtypes.
Results SNPs in seven genes including SLC1A3, SLC6A3, HTR4, ADRA1A, HTR2A, SNAP25, and COMT showed a nominal level of association with ADHD (P values < 0.05), but none remained significant after a stringent correction for the total number of tests performed.
Conclusion The strongest signal emerged from SNPs in the promoter region (rs3808585) and in an intron (rs17426222, rs4732682, rs573514) of ADRA1A, all located within the same haplotype block. Some of the SNPs in HTR2A and COMT have already been reported by others, whereas other SNPs will need confirmation in independent samples. Psychiatr Genet 19:134-141 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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Details
- Title
- Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A
- Creators
- Josephine Elia - Center for Applied GenomicsMario Capasso - IRCCS SDNZafar Zaheer - University of PennsylvaniaFrancesca Lantieri - University of GenoaPaul Ambrosini - Drexel UniversityWade Berrettini - University of PennsylvaniaMarcella Devoto - University of PennsylvaniaHakon Hakonarson - University of Pennsylvania
- Publication Details
- Psychiatric genetics, v 19(3)
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 8
- Grant note
- K23MH066275-01 / NIMH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) UL1-RR-024134 / National Center for Research Resources; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) K23MH066275 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) UL1RR024134 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000265952100004
- Scopus ID
- 2-s2.0-67649198996
- Other Identifier
- 991019167849504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Genetics & Heredity
- Neurosciences