Journal article
Candidate high myopia loci on chromosomes 18p and 12q do not play a major role in susceptibility to common myopia
BMC medical genetics, v 5(1), 20
03 Aug 2004
PMID: 15291966
Abstract
Background
To determine whether previously reported loci predisposing to nonsyndromic high myopia show linkage to common myopia in pedigrees from two ethnic groups: Ashkenazi Jewish and Amish. We hypothesized that these high myopia loci might exhibit allelic heterogeneity and be responsible for moderate /mild or common myopia.
Methods
Cycloplegic and manifest refraction were performed on 38 Jewish and 40 Amish families. Individuals with at least -1.00 D in each meridian of both eyes were classified as myopic. Genomic DNA was genotyped with 12 markers on chromosomes 12q21-23 and 18p11.3. Parametric and nonparametric linkage analyses were conducted to determine whether susceptibility alleles at these loci are important in families with less severe, clinical forms of myopia.
Results
There was no strong evidence of linkage of common myopia to these candidate regions: all two-point and multipoint heterogeneity LOD scores were < 1.0 and non-parametric linkage p-values were > 0.01. However, one Amish family showed slight evidence of linkage (LOD>1.0) on 12q; another 3 Amish families each gave LOD >1.0 on 18p; and 3 Jewish families each gave LOD >1.0 on 12q.
Conclusions
Significant evidence of linkage (LOD> 3) of myopia was not found on chromosome 18p or 12q loci in these families. These results suggest that these loci do not play a major role in the causation of common myopia in our families studied.
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Details
- Title
- Candidate high myopia loci on chromosomes 18p and 12q do not play a major role in susceptibility to common myopia
- Creators
- Grace Ibay - National Institutes of HealthBetty Doan - National Institutes of HealthLauren Reider - University of PennsylvaniaDebra Dana - University of PennsylvaniaMelissa Schlifka - University of PennsylvaniaHeping Hu - National Institutes of HealthTaura Holmes - National Institutes of HealthJennifer O'Neill - National Institutes of HealthRobert Owens - University of PennsylvaniaElise Ciner - Salus UniversityJoan E Bailey–Wilson - University of PennsylvaniaDwight Stambolian - University of Pennsylvania
- Publication Details
- BMC medical genetics, v 5(1), 20
- Publisher
- BioMed Central
- Number of pages
- 1
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pennsylvania College of Optometry (PCO)
- Scopus ID
- 2-s2.0-26444438725
- Other Identifier
- 991022089046804721