Journal article
Cannabinoid and opioid interactions: Implications for opiate dependence and withdrawal
Neuroscience, v 248, pp 637-654
17 Sep 2013
PMID: 23624062
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
•Review of the problem of opioid dependence and withdrawal.•Review of cannabinoid effects on noradrenergic circuitry.•Review of cannabinoid opioid cross-talk.•Targeting cannabinoid opioid interactions in novel therapeutic approaches.
Withdrawal from opiates, such as heroin or oral narcotics, is characterized by a host of aversive physical and emotional symptoms. High rates of relapse and limited treatment success rates for opiate addiction have prompted a search for new approaches. For many opiate addicts, achieving abstinence may be further complicated by poly-drug use and co-morbid mental disorders. Research over the past decade has shed light on the influence of endocannabinoids (ECs) on the opioid system. Evidence from both animal and clinical studies point toward an interaction between these two systems, and suggest that targeting the EC system may provide novel interventions for managing opiate dependence and withdrawal. This review will summarize the literature surrounding the molecular effects of cannabinoids and opioids on the locus coeruleus–norepinephrine system, a key circuit implicated in the negative sequelae of opiate addiction. A consideration of the trends and effects of marijuana use in those seeking treatment to abstain from opiates in the clinical setting will also be presented. In summary, the present review details how cannabinoid–opioid interactions may inform novel interventions in the management of opiate dependence and withdrawal.
Metrics
Details
- Title
- Cannabinoid and opioid interactions: Implications for opiate dependence and withdrawal
- Creators
- J.L. Scavone - Thomas Jefferson UniversityR.C. Sterling - Thomas Jefferson UniversityE.J. Van Bockstaele - Thomas Jefferson University
- Publication Details
- Neuroscience, v 248, pp 637-654
- Publisher
- Elsevier
- Number of pages
- 18
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000330422100057
- Scopus ID
- 2-s2.0-84881367408
- Other Identifier
- 991021903409204721
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Source: SDGs in the Output
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- Web of Science research areas
- Neurosciences