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Journal article
Cannabinoid modulation of noradrenergic circuits: Implications for psychiatric disorders
Progress in neuro-psychopharmacology & biological psychiatry, v 38(1), pp 59-67
02 Jul 2012
PMID: 22296986
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The interaction between the endocannabinoid system and catecholaminergic circuits has gained increasing attention as it is recognized that the development of synthetic cannabinoid receptor agonists/antagonists or compounds targeting endocannabinoid synthesis/metabolism may hold some therapeutic potential for the treatment of psychiatric disorders. The noradrenergic system plays a critical role in the modulation of emotional state, primarily related to anxiety, arousal, and stress. Recent evidence suggests that the endocannabinoid system mediates stress responses and emotional homeostasis, in part, by targeting noradrenergic circuits. This review summarizes our current knowledge regarding the anatomical substrates underlying regulation of noradrenergic circuitry by the endocannabinoid system. It then presents biochemical evidence showing an important effect of cannabinoid modulation on adrenergic receptor signaling. Finally, new evidence from behavioral pharmacology studies is provided demonstrating that norepinephrine is a critical determinant of cannabinoid-induced aversion, adding another dimension to how central noradrenergic circuitry is regulated by the cannabinoid system. (C) 2012 Elsevier Inc. All rights reserved.
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Details
- Title
- Cannabinoid modulation of noradrenergic circuits: Implications for psychiatric disorders
- Creators
- Ana Franky Carvalho - Thomas Jefferson UniversityElisabeth J. Van Bockstaele - Jefferson Hospital for Neuroscience
- Publication Details
- Progress in neuro-psychopharmacology & biological psychiatry, v 38(1), pp 59-67
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- DA020129 / NIDA; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA) R01DA020129 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000307258200008
- Scopus ID
- 2-s2.0-84862871685
- Other Identifier
- 991021903403004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences
- Pharmacology & Pharmacy
- Psychiatry