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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Cannabinoid receptors are localized to noradrenergic axon terminals in the rat frontal cortex
Brain research, v 1127(1), pp 36-44
05 Jan 2007
PMID: 17113043
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cannabinoid agonists exert complex actions on modulatory neurotransmitters involved in attention and cognition. Previous studies have demonstrated that acute systemic administration of the synthetic cannabinoid agonist, WIN 55,212-2, increases norepinephrine efflux in the rat frontal cortex. In an effort to elucidate whether cannabinoid (CB1) receptors are positioned to presynaptically modulate norepinephrine release in the frontal cortex, immunocytochemical detection of the CB1 receptor and the catecholamine-synthesizing enzyme dopamine-β-hydroxylase (DβH) was performed using confocal immunofluorescence microscopy and immunoelectron microscopy in rat brain. Fluorescence microscopy analysis of dually labeled tissue sections from the frontal cortex indicated that individual axonal processes exhibited both CB1 receptor and DβH immunoreactivities. Ultrastructural analysis confirmed that one-third of axon terminals containing CB1 immunolabeling also exhibited DβH labeling. Cortical neurons were also found to be targeted by separately labeled CB1- and DβH-containing axon terminals. In conclusion, the present neuroanatomical data suggest that cortical norepinephrine release may be modulated, in part, by CB1 receptors that are presynaptically distributed on noradrenergic axon terminals.
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Details
- Title
- Cannabinoid receptors are localized to noradrenergic axon terminals in the rat frontal cortex
- Creators
- Veronica C. Oropeza - Thomas Jefferson UniversityKenneth Mackie - University of WashingtonElisabeth J. Van Bockstaele - Thomas Jefferson University
- Publication Details
- Brain research, v 1127(1), pp 36-44
- Publisher
- Elsevier
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000243827400005
- Scopus ID
- 2-s2.0-33845190636
- Other Identifier
- 991021903294704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences