Journal article
Carbon Nanotube‐Tipped Endoscope for In Situ Intracellular Surface‐Enhanced Raman Spectroscopy
Small (Weinheim an der Bergstrasse, Germany), v 7(4), pp 540-545
18 Feb 2011
PMID: 21360811
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Gold nanoparticle‐decorated carbon nanotubes (CNTs) are used to study intracellular environments in situ using surface‐enhanced Raman spectroscopy (SERS). CNTs are decorated with gold nanoparticles and assembled onto the tips of pulled glass capillaries to form a SERS‐enabled endoscope. The sub‐micrometer size and high mechanical strength of the endoscope make it possible to penetrate the cell membrane for intracellular probing and remain positioned inside during lengthy SERS measurements without causing damage to the cell. Using the SERS‐enabled endoscope, DNA and other biomolecules are detected in situ within the nucleus of a single human cervical carcinoma cell in a minimally invasive manner. The SERS‐enabled endoscopes exhibit high selectivity and sensitivity for detecting trace amounts of analytes (≈1 pM) in biofluid environments, highlighting their capabilities as label‐free, biological sensors for real‐time in situ cellular diagnostics, biological detection, and pharmaceutical research.
Carbon nanotubes decorated with gold nanoparticles form a surface‐enhanced Raman spectroscopy (SERS)‐enabled endoscope. The SERS‐enabled endoscope is used to detect DNA and other biomolecules in situ within the nucleus of a single human cervical carcinoma cell in a minimally invasive manner.
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Details
- Title
- Carbon Nanotube‐Tipped Endoscope for In Situ Intracellular Surface‐Enhanced Raman Spectroscopy
- Creators
- Jun Jie NiuMichael G SchrlauGary FriedmanYury Gogotsi
- Publication Details
- Small (Weinheim an der Bergstrasse, Germany), v 7(4), pp 540-545
- Publisher
- WILEY‐VCH Verlag; Weinheim
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Electrical and Computer Engineering; Materials Science and Engineering
- Web of Science ID
- WOS:000288080400016
- Scopus ID
- 2-s2.0-79952305681
- Other Identifier
- 991014878449604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Multidisciplinary
- Chemistry, Physical
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology
- Physics, Applied
- Physics, Condensed Matter