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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Carbon Source Metabolism and Its Regulation in Cancer Cells
Critical reviews in eukaryotic gene expression, v 22(1), pp 17-35
01 Jan 2012
PMID: 22339657
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cancer cell proliferation and progression require sufficient supplies of nutrients including carbon sources, nitrogen sources, and molecular oxygen. Particularly, carbon sources and molecular oxygen are critical for the generation of ATP and building blocks, and for the maintenance of intracellular redox status. However, solid tumors frequently outgrow the blood supply, resulting in nutrient insufficiency. Accordingly, cancer cell metabolism shows aberrant biochemical features that are consequences of oncogenic signaling and adaptation. Those adaptive metabolism features, including the Warburg effect and addiction to glutamine, may form the biochemical basis for resistance to chemotherapy and radiation. A better understanding of the regulatory mechanisms that link the signaling pathways to adaptive metabolic reprogramming may identify novel biomarkers for drug development. In this review, we focus on the regulation of carbon source utilization at a cellular level, emphasizing its relevance to proliferative biosynthesis in cancer cells. We summarize the essential needs of proliferating cells and the metabolic features of glucose, lipids, and glutamine, and we review the roles of transcription regulators (i.e., HIF-1, c-Myc, and p53) and two major oncogenic signaling pathways (i.e., PI3K-Akt and MAPK) in regulating the utilization of carbon sources. Finally, the effects of glucose on cell proliferation and perspective from both biochemical and cellular angles are discussed.
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Details
- Title
- Carbon Source Metabolism and Its Regulation in Cancer Cells
- Creators
- Chengqian Yin - Drexel UniversityShuo Qie - Drexel UniversityNianli Sang - Drexel University
- Publication Details
- Critical reviews in eukaryotic gene expression, v 22(1), pp 17-35
- Publisher
- Begell House Inc
- Number of pages
- 19
- Grant note
- Drexel University R01CA129494 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R01-CA129494 / National Cancer Institute (NCI), the National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; Biology
- Web of Science ID
- WOS:000300966600002
- Scopus ID
- 2-s2.0-84860316773
- Other Identifier
- 991019167623504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Genetics & Heredity