Journal article
Carbon monoxide releasing molecule-2 decreases thick diameter fibrin fibre formation in normal and factor XIII deficient plasmas
Blood coagulation & fibrinolysis, v 21(1), pp 101-105
01 Jan 2010
PMID: 19844175
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Carbon monoxide derived from carbon monoxide releasing molecules (CORMs) has been demonstrated to enhance normal plasma thrombus speed of growth and strength as well as diminish vulnerability to fibrinolysis in vitro. We tested the hypothesis that tricarbonyldichlororuthenium (11) dimer (CORM-2) would modify plasma thrombi ultrastructure as determined by electron microscopy. Normal and FXIII-deficient (<1% normal activity) plasmas were exposed to 0 or 100 mu mol/l CORM-2, with coagulation initiated with tissue factor followed by a 15 min incubation at 37 degrees C prior to fixation. Transmission electron microscopy of the four conditions was conducted at 5000-60000-fold magnification. CORM-2 markedly diminished the formation of thick diameter fibrin fibres in normal plasma and FXIII-deficient plasma. The density of thin diameter fibrin fibres did not seem to be changed by CORM-2 in normal plasma, but was increased in FXIII-deficient plasma. CORM-2 significantly modifies thrombin-mediated polymerization of fibrin. This finding may partially explain how CORM-2 exposure results in stronger thrombi resistant to fibrinolysis. Blood Coagul Fibrinolysis 21:101-105 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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Details
- Title
- Carbon monoxide releasing molecule-2 decreases thick diameter fibrin fibre formation in normal and factor XIII deficient plasmas
- Creators
- Vance G. Nielsen - Drexel UniversityJames K. Kirklin - University of Alabama at BirminghamJames F. George - University of Alabama at BirminghamJeffrey D. Messinger - University of Alabama at Birmingham
- Publication Details
- Blood coagulation & fibrinolysis, v 21(1), pp 101-105
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 5
- Grant note
- Departments of Anesthesiology and Surgery
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000273692800018
- Scopus ID
- 2-s2.0-75649133252
- Other Identifier
- 991019357633704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Hematology