Journal article
Carbon monoxide releasing molecule-2 increases the velocity of thrombus growth and strength in human plasma
Blood coagulation & fibrinolysis, v 20(5), pp 377-380
Jul 2009
PMID: 19417630
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Carbon monoxide derived from degradation of heme by heme oxygenase or carbon monoxide releasing molecules (CORMs) has been demonstrated to decrease thrombosis in vivo and to weakly inhibit platelet aggregation. We tested the hypothesis that carbon monoxide released from tricarbonyldichlororuthenium (II) dimer (CORM-2) would diminish the velocity of formation and strength of plasma thrombi as determined by thrombelastography. Normal plasma was exposed to 0 or 100 micromol/l CORM-2 or inactivated CORM-2 (iCORM-2), with coagulation initiated with tissue factor or celite (n = 8 per condition). Additional experiments utilized factor XIII (FXIII) deficient plasma activated with celite. Coagulation kinetics was monitored with thrombelastography for 15 min. CORM-2, and to a lesser extent, iCORM-2, significantly (P < 0.05) increased the velocity of formation (122 and 56%, respectively) and strength (66 and 57%, respectively) of plasma clots initiated with either tissue factor or celite compared with thrombi not exposed to CORM-2 or iCORM. In FXIII deficient plasma CORM-2 significantly increased the velocity of clot formation (264%) and strength (240%). Carbon monoxide and iCORM-2 derived from CORM-2 markedly enhance the velocity of clot growth and strength. These findings serve as the rationale for further investigations to determine if CORMs could be utilized as hemostatic agents.
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Details
- Title
- Carbon monoxide releasing molecule-2 increases the velocity of thrombus growth and strength in human plasma
- Creators
- Vance G Nielsen - University of Alabama at BirminghamJames K Kirklin - University of Alabama at BirminghamJames F George - University of Alabama at Birmingham
- Publication Details
- Blood coagulation & fibrinolysis, v 20(5), pp 377-380
- Publisher
- Lippincott
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000267632900013
- Scopus ID
- 2-s2.0-68149089854
- Other Identifier
- 991019357763904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Hematology