Logo image
Back
Cardiac Reverse Remodeling Mediated by HeartMate 3 Left Ventricular Assist Device: Comparison to Older Generation Devices
Journal article   Peer reviewed

Cardiac Reverse Remodeling Mediated by HeartMate 3 Left Ventricular Assist Device: Comparison to Older Generation Devices

Michael Yaoyao Yin, Eleni Maneta, Christos P. Kyriakopoulos, Alexander T. Michaels, Leonard D. Genovese, Mahathi B. Indaram, Omar Wever-Pinzon, Ramesh Singh, Eleni Tseliou, Iosif Taleb, …
ASAIO journal (1992)
29 May 2024
DOI: https://doi.org/10.1097/MAT.0000000000002245
PMID: 38810218
url
https://pmc.ncbi.nlm.nih.gov/articles/PMC11604816/pdf/nihms-2008348.pdfView
Open

Abstract

Currently, the fully magnetically levitated left ventricular assist device (LVAD) HeartMate 3 (HM3) is the only commercially available device for advanced heart failure (HF) patients. However, the left ventricular (LV) functional and structural changes following mechanical unloading and circulatory support (MCS) with the HM3 have not been investigated. We compared the reverse remodeling induced by the HM3 to older generation continuous-flow LVADs. Chronic HF patients (n = 405) undergoing MCS with HeartWare Ventricular Assist Device (HVAD, n = 115), HM3 (n = 186), and HeartMate II (HM2, n = 104) at four programs were included. Echocardiograms were obtained preimplant and at 1, 3, 6, and 12 months following LVAD implantation. There were no differences in the postimplant serial LV ejection fraction (LVEF) between the devices. The postimplant LV internal diastolic diameter (LVIDd) was significantly lower for HM2 at 3 and 6 months compared with HVAD and HM3. The proportion of patients achieving “cardiac reverse remodeling responder” status (defined as LVEF improvement to ≥40% and LVIDD ≤5.9 cm) was 11.9%, and was similar between devices. HeartMate 3 appears to result in similar cardiac reverse remodeling as older generation CF-LVADs, suggesting that the fully magnetically levitated device technology could provide an effective platform to further study and promote cardiac reverse remodeling.

Metrics

7 Record Views
3 citations in Scopus

Details

Logo image