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Journal article
Cardiac Systolic and Diastolic Dysfunction After a Cholesterol-Rich Diet
Circulation (New York, N.Y.), v 109(1), pp 97-102
06 Jan 2004
PMID: 14676147
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background—
Although hypercholesterolemia is a well-established risk factor for coronary artery disease, little is known regarding its direct effects on cardiac function.
Methods and Results—
We examined the effects of cholesterol feeding (0.5%) on cardiac function in rabbits. After 10 weeks, both systolic shortening and diastolic relaxation rates were impaired without any change in aortic pressure or ventricular hypertrophy. However, sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA)-2 mRNA levels were reduced within 4 days after initiation of cholesterol feeding. After this effect, SERCA-2 protein and SERCA-mediated Ca uptake into sarcoplasmic reticulum vesicles were impaired, and the ratio of MHC-β to MHC-α mRNA increased 5-fold. Suppression of the SERCA-2 message correlated temporally with enrichment of the cardiac sarcolemma with cholesterol.
Conclusions—
These data demonstrate that dietary hypercholesterolemia induces a “cholesterol cardiomyopathy” characterized by systolic and diastolic dysfunction. These alterations were independent of vascular disease and demonstrate a dietary link to cardiac dysfunction.
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Details
- Title
- Cardiac Systolic and Diastolic Dysfunction After a Cholesterol-Rich Diet
- Creators
- Y. Huang - Thomas Jefferson UniversityK.E. WalkerF. HanleyJ. NarulaS.R. HouserT.N. Tulenko
- Publication Details
- Circulation (New York, N.Y.), v 109(1), pp 97-102
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Marketing
- Web of Science ID
- WOS:000187791900020
- Scopus ID
- 2-s2.0-0346096805
- Other Identifier
- 991019167607304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Peripheral Vascular Disease